Screening for muscle wasting and dysfunction in patients with chronic kidney disease

Screening for muscle wasting and dysfunction in patients with chronic kidney disease

Author Carrero, Juan J. Google Scholar
Johansen, Kirsten L. Google Scholar
Lindholm, Bengt Google Scholar
Stenvinkel, Peter Google Scholar
Cuppari, Lilian Autor UNIFESP Google Scholar
Avesani, Carla M. Google Scholar
Abstract Skeletal muscle mass and muscle function are negatively affected by a variety of conditions inherent to chronic kidney disease (CKD) and to dialysis treatment. Skeletal muscle mass and function serve as indicators of the nutritional and clinical state of CKD patients, and low values or derangements over time are strong predictors of poor patient outcomes. However, muscle size and function can be affected by different factors, may decline at different rates, and may have different patient implications. Therefore, operational definitions of frailty and sarcopenia have emerged to encompass these 2 dimensions of muscle health, i.e., size and functionality. The aim of this review is to appraise available methods for assessment of muscle mass and functionality, with an emphasis on their accuracy in the setting of CKD patients. We then discuss the selection of reference cutoffs for defining conditions of muscle wasting and dysfunction. Finally, we review definitions applied in studies addressing sarcopenia and frailty in CKD patients and discuss their applicability for diagnosis and monitoring.
Keywords frailty
muscle function
muscle mass
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor Stockholm County Council
Swedish Heart and Lung Foundation
Westman Foundation
National Institute for Diabetes and Digestive and Kidney Diseases of the National Institutes of Health
Karolinska Institutet Diabetes Centre
Swedish Medical Research Council
Westmans Foundation
National Council of Technological and Scientific Development (CNPq)
Oswaldo Ramos Foundation
Baxter Healthcare
Date 2016
Published in Kidney International. New York, v. 90, n. 1, p. 53-66, 2016.
ISSN 0085-2538 (Sherpa/Romeo, impact factor)
Publisher Nature Publishing Group
Extent 53-66
Access rights Closed access
Type Article
Web of Science ID WOS:000377929400015

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