Screening for muscle wasting and dysfunction in patients with chronic kidney disease

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dc.citation.issue1
dc.citation.volume90
dc.contributor.authorCarrero, Juan J.
dc.contributor.authorJohansen, Kirsten L.
dc.contributor.authorLindholm, Bengt
dc.contributor.authorStenvinkel, Peter
dc.contributor.authorCuppari, Lilian [UNIFESP]
dc.contributor.authorAvesani, Carla M.
dc.coverageNew York
dc.date.accessioned2020-08-14T13:44:30Z
dc.date.available2020-08-14T13:44:30Z
dc.date.issued2016
dc.description.abstractSkeletal muscle mass and muscle function are negatively affected by a variety of conditions inherent to chronic kidney disease (CKD) and to dialysis treatment. Skeletal muscle mass and function serve as indicators of the nutritional and clinical state of CKD patients, and low values or derangements over time are strong predictors of poor patient outcomes. However, muscle size and function can be affected by different factors, may decline at different rates, and may have different patient implications. Therefore, operational definitions of frailty and sarcopenia have emerged to encompass these 2 dimensions of muscle health, i.e., size and functionality. The aim of this review is to appraise available methods for assessment of muscle mass and functionality, with an emphasis on their accuracy in the setting of CKD patients. We then discuss the selection of reference cutoffs for defining conditions of muscle wasting and dysfunction. Finally, we review definitions applied in studies addressing sarcopenia and frailty in CKD patients and discuss their applicability for diagnosis and monitoring.en
dc.description.affiliationKarolinska Inst, Div Renal Med, SE-14186 Stockholm, Sweden
dc.description.affiliationKarolinska Inst, Baxter Novum, SE-14186 Stockholm, Sweden
dc.description.affiliationKarolinska Inst, Ctr Mol Med, SE-14186 Stockholm, Sweden
dc.description.affiliationUniv Calif San Francisco, Div Nephrol, San Francisco, CA 94143 USA
dc.description.affiliationUniv Fed Sao Paulo, Div Nephrol, Sao Paulo, Brazil
dc.description.affiliationUniv Estado Rio De Janeiro, Inst Nutr, Dept Appl Nutr, Rio De Janeiro, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Nephrol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipStockholm County Council
dc.description.sponsorshipSwedish Heart and Lung Foundation
dc.description.sponsorshipWestman Foundation
dc.description.sponsorshipNational Institute for Diabetes and Digestive and Kidney Diseases of the National Institutes of Health
dc.description.sponsorshipKarolinska Institutet Diabetes Centre
dc.description.sponsorshipSwedish Medical Research Council
dc.description.sponsorshipWestmans Foundation
dc.description.sponsorshipNational Council of Technological and Scientific Development (CNPq)
dc.description.sponsorshipOswaldo Ramos Foundation
dc.description.sponsorshipBaxter Healthcare
dc.format.extent53-66
dc.identifierhttp://dx.doi.org/10.1016/j.kint.2016.02.025
dc.identifier.citationKidney International. New York, v. 90, n. 1, p. 53-66, 2016.
dc.identifier.doi10.1016/j.kint.2016.02.025
dc.identifier.issn0085-2538
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57703
dc.identifier.wosWOS:000377929400015
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofKidney International
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectfrailtyen
dc.subjectmuscle functionen
dc.subjectmuscle massen
dc.subjectsarcopeniaen
dc.subjectstrengthen
dc.titleScreening for muscle wasting and dysfunction in patients with chronic kidney diseaseen
dc.typeinfo:eu-repo/semantics/article
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