Role of aryl hydrocarbon receptor in mesenchymal stromal cell activation: A minireview
Arquivos
Data
2017
Autores
de Almeida, Danilo Candido 
Martins Evangelista, Laura Sibele
Saraiva Camara, Niels Olsen
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Mesenchymal stromal cells (MSCs) possess great therapeutic advantages due to their ability to produce a diverse array of trophic/growth factors related to cytoprotection and immunoregulation. MSC activation via specific receptors is a crucial event for these cells to exert their immunosuppressive response. The aryl-hydrocarbon receptor (AhR) is a sensitive molecule for external signals and it is expressed in MSCs and, upon positive activation, may potentially regulate the MSC-associated immunomodulatory function. Consequently, signalling pathways linked to AhR activation can elucidate some of the molecular cascades involved in MSC-mediated immunosuppression. In this minireview, we have noted some important findings concerning MSC regulation via AhR, highlighting that its activation is associated with improvement in migration and immunoregulation, as well as an increase in pro-regenerative potential. Thus, AhR-mediated MSC activation can contribute to new perspectives on MSC-based therapies, particularly those directed at immune-associated disorders.
Descrição
Citação
World Journal Of Stem Cells. Pleasanton, v. 9, n. 9, p. 152-158, 2017.