Role of aryl hydrocarbon receptor in mesenchymal stromal cell activation: A minireview

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dc.citation.issue9
dc.citation.volume9
dc.contributor.authorde Almeida, Danilo Candido [UNIFESP]
dc.contributor.authorMartins Evangelista, Laura Sibele [UNIFESP]
dc.contributor.authorSaraiva Camara, Niels Olsen [UNIFESP]
dc.coveragePleasanton
dc.date.accessioned2020-08-04T13:40:10Z
dc.date.available2020-08-04T13:40:10Z
dc.date.issued2017
dc.description.abstractMesenchymal stromal cells (MSCs) possess great therapeutic advantages due to their ability to produce a diverse array of trophic/growth factors related to cytoprotection and immunoregulation. MSC activation via specific receptors is a crucial event for these cells to exert their immunosuppressive response. The aryl-hydrocarbon receptor (AhR) is a sensitive molecule for external signals and it is expressed in MSCs and, upon positive activation, may potentially regulate the MSC-associated immunomodulatory function. Consequently, signalling pathways linked to AhR activation can elucidate some of the molecular cascades involved in MSC-mediated immunosuppression. In this minireview, we have noted some important findings concerning MSC regulation via AhR, highlighting that its activation is associated with improvement in migration and immunoregulation, as well as an increase in pro-regenerative potential. Thus, AhR-mediated MSC activation can contribute to new perspectives on MSC-based therapies, particularly those directed at immune-associated disorders.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Med, Div Nephrol, Rua Pedro Toledo,669-10 Andar Frente, BR-04039003 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Immunol, BR-05508000 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Med, Div Nephrol, Rua Pedro Toledo,669-10 Andar Frente, BR-04039003 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Sao Paulo, Inst Biomed Sci, Dept Immunol, BR-05508000 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Public Foundation FAPESP
dc.description.sponsorshipNational Counsel of Technological and Scientific Development CNPq
dc.description.sponsorshipIDCNPq: 07/07193-3
dc.description.sponsorshipIDCNPq: 12/02270-2
dc.format.extent152-158
dc.identifierhttp://dx.doi.org/10.4252/wjsc.v9.i9.152
dc.identifier.citationWorld Journal Of Stem Cells. Pleasanton, v. 9, n. 9, p. 152-158, 2017.
dc.identifier.doi10.4252/wjsc.v9.i9.152
dc.identifier.fileWOS000411177000002.pdf
dc.identifier.issn1948-0210
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57347
dc.identifier.wosWOS:000411177000002
dc.language.isoeng
dc.publisherBaishideng Publishing Group Inc
dc.relation.ispartofWorld Journal Of Stem Cells
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMesenchymal stromal cellsen
dc.subjectAryl-hydrocarbon receptoren
dc.subjectCell activation and immunosuppressionen
dc.titleRole of aryl hydrocarbon receptor in mesenchymal stromal cell activation: A minireviewen
dc.typeinfo:eu-repo/semantics/article
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