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Modulation of Toll Like Receptor-2 on sebaceous gland by the treatment of adult female acne

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Date
2017
Author
Rocha, Marco A. D. [UNIFESP]
Guadanhim, Lilia R. S. [UNIFESP]
Sanudo, Adriana [UNIFESP]
Bagatin, Edileia [UNIFESP]
Type
Artigo
ISSN
1938-1972
Is part of
Dermato-Endocrinology
DOI
10.1080/19381980.2017.1361570
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Abstract
Adult female acne is a chronic inflammatory, immune-mediated disease that affects the pilosebaceous unit in women in their 20s to 40s, and is considered different from acne vulgaris. Propionibacterium acnes is recognized by TLR-2, resulting in activation of this receptor and an inflammatory response through the NF kappa B pathway. This therapeutic, interventional, open, randomized, evaluator-blinded and comparative trial included 38 adult women with moderate facial acne and 10 age-matched controls, all aged between 26 and 44 years. Two treatments were performed over six months: 15% azelaic acid gel (AA) bid (n = 18) and oral contraceptive (COC) drospirenone 3 mg/ethinylestradiol .02 mg (n = 20). Biopsies were taken at baseline (control, lesion, perilesional) and at the conclusion (lesion and perilesional) of the study to evaluate TLR-2 expression by immunohistochemistry. Lesion count and blind photographic evaluation were used for efficacy. The groups were homogeneous: 70% of lesions were located in the submandibular area, 95% of participants had inflammatory lesions
 
of these, 50% had persistent and 50% had late-onset acne. The mean ages were 33.7 +/- 5.5 and 33.1 +/- 5.3 years (COC and AA group, respectively). A moderate clinical improvement was observed in both groups. No difference in TLR-2 expression in the lesion or perilesional areas was observed
 
however, reduced TLR-2 expression was seen in the control group. A significant reduction in expression was observed after both treatments, with no difference between the groups. This finding suggests an anti-inflammatory effect of COCs and AA in adult female acne, via modulation of the TLR-2 receptor.
 
Citation
Dermato-Endocrinology. Philadelphia, v. 9, n. 1, p. -, 2017.
Keywords
Acne
toll-like receptor 2
combined oral contraceptive
azelaic acid
sebaceous glands
Sponsorship
Dermatology - Sao Paulo Regional of Brazilian
Society of Dermatology - FUNADERSP
URI
https://repositorio.unifesp.br/handle/11600/57160
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  • EPM - Artigos [16303]

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