Modulation of Toll Like Receptor-2 on sebaceous gland by the treatment of adult female acne

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dc.citation.issue1
dc.citation.volume9
dc.contributor.authorRocha, Marco A. D. [UNIFESP]
dc.contributor.authorGuadanhim, Lilia R. S. [UNIFESP]
dc.contributor.authorSanudo, Adriana [UNIFESP]
dc.contributor.authorBagatin, Edileia [UNIFESP]
dc.coveragePhiladelphia
dc.date.accessioned2020-08-04T13:39:52Z
dc.date.available2020-08-04T13:39:52Z
dc.date.issued2017
dc.description.abstractAdult female acne is a chronic inflammatory, immune-mediated disease that affects the pilosebaceous unit in women in their 20s to 40s, and is considered different from acne vulgaris. Propionibacterium acnes is recognized by TLR-2, resulting in activation of this receptor and an inflammatory response through the NF kappa B pathway. This therapeutic, interventional, open, randomized, evaluator-blinded and comparative trial included 38 adult women with moderate facial acne and 10 age-matched controls, all aged between 26 and 44 years. Two treatments were performed over six months: 15% azelaic acid gel (AA) bid (n = 18) and oral contraceptive (COC) drospirenone 3 mg/ethinylestradiol .02 mg (n = 20). Biopsies were taken at baseline (control, lesion, perilesional) and at the conclusion (lesion and perilesional) of the study to evaluate TLR-2 expression by immunohistochemistry. Lesion count and blind photographic evaluation were used for efficacy. The groups were homogeneous: 70% of lesions were located in the submandibular area, 95% of participants had inflammatory lesionsen
dc.description.abstractof these, 50% had persistent and 50% had late-onset acne. The mean ages were 33.7 +/- 5.5 and 33.1 +/- 5.3 years (COC and AA group, respectively). A moderate clinical improvement was observed in both groups. No difference in TLR-2 expression in the lesion or perilesional areas was observeden
dc.description.abstracthowever, reduced TLR-2 expression was seen in the control group. A significant reduction in expression was observed after both treatments, with no difference between the groups. This finding suggests an anti-inflammatory effect of COCs and AA in adult female acne, via modulation of the TLR-2 receptor.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Prevent Med, Dept Dermatol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Prevent Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Prevent Med, Dept Dermatol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Prevent Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipDermatology - Sao Paulo Regional of Brazilian
dc.description.sponsorshipSociety of Dermatology - FUNADERSP
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1080/19381980.2017.1361570
dc.identifier.citationDermato-Endocrinology. Philadelphia, v. 9, n. 1, p. -, 2017.
dc.identifier.doi10.1080/19381980.2017.1361570
dc.identifier.fileWOS000428315000001.pdf
dc.identifier.issn1938-1972
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57160
dc.identifier.wosWOS:000428315000001
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofDermato-Endocrinology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcneen
dc.subjecttoll-like receptor 2en
dc.subjectcombined oral contraceptiveen
dc.subjectazelaic aciden
dc.subjectsebaceous glandsen
dc.titleModulation of Toll Like Receptor-2 on sebaceous gland by the treatment of adult female acneen
dc.typeinfo:eu-repo/semantics/article
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