Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer

View/Open
Date
2016
Author
da Silva Oliveira, Kelly Cristina
Thomaz Araujo, Taissa Maira
Albuquerque, Camila Inagaki
Barata, Gabriela Alcantara
Gigek, Carolina Oliveira [UNIFESP]
Leal, Mariana Ferreira [UNIFESP]
Wisnieski, Fernanda [UNIFESP]
Rodrigues Mello Junior, Fernando Augusto
Khayat, Andre Salim
de Assumpcao, Paulo Pimentel
Rodriguez Burbano, Rommel Mario
Smith, Marilia de Arruda Cardoso [UNIFESP]
Calcagno, Danielle Queiroz
Type
Artigo
ISSN
1007-9327
Is part of
World Journal Of Gastroenterology
DOI
10.3748/wjg.v22.i35.7951
Metadata
Show full item record
Abstract
Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic miRNAs and downregulated tumour-suppressor miRNAs in this type of cancer. In this review, we provide an overview of the role of miRNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on miRNA activity.
Citation
World Journal Of Gastroenterology. Pleasanton, v. 22, n. 35, p. 7951-7962, 2016.
Keywords
Gastric cancer
Epigenetic
Diagnostic biomarkers
miRNAs
Prognostic biomarkers
Sponsorship
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
URI
https://repositorio.unifesp.br/handle/11600/57102
Collections