Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer

da Silva Oliveira, Kelly Cristina; Thomaz Araujo, Taissa Maira; Albuquerque, Camila Inagaki; Barata, Gabriela Alcantara; Gigek, Carolina Oliveira [UNIFESP]; Leal, Mariana Ferreira [UNIFESP]; Wisnieski, Fernanda [UNIFESP]; Rodrigues Mello Junior, Fernando Augusto; Khayat, Andre Salim; de Assumpcao, Paulo Pimentel; Rodriguez Burbano, Rommel Mario; Smith, Marilia de Arruda Cardoso [UNIFESP]; Calcagno, Danielle Queiroz

Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer

Arquivos

WOS000383981800008.pdf(1022.97 KB)

Data

2016

Autores

da Silva Oliveira, Kelly Cristina

Thomaz Araujo, Taissa Maira

Albuquerque, Camila Inagaki

Barata, Gabriela Alcantara

Gigek, Carolina Oliveira

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Tipo

Artigo

Resumo

Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic miRNAs and downregulated tumour-suppressor miRNAs in this type of cancer. In this review, we provide an overview of the role of miRNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on miRNA activity.

Citação

World Journal Of Gastroenterology. Pleasanton, v. 22, n. 35, p. 7951-7962, 2016.