Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer
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Data
2016
Autores
da Silva Oliveira, Kelly Cristina
Thomaz Araujo, Taissa Maira
Albuquerque, Camila Inagaki
Barata, Gabriela Alcantara
Gigek, Carolina Oliveira [UNIFESP]
Leal, Mariana Ferreira [UNIFESP]
Wisnieski, Fernanda [UNIFESP]
Rodrigues Mello Junior, Fernando Augusto
Khayat, Andre Salim
de Assumpcao, Paulo Pimentel
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Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic miRNAs and downregulated tumour-suppressor miRNAs in this type of cancer. In this review, we provide an overview of the role of miRNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on miRNA activity.
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World Journal Of Gastroenterology. Pleasanton, v. 22, n. 35, p. 7951-7962, 2016.