Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
Data
2016
Autores
Souza, Paulo Victor Sgobbi de 
Pinto, Wladimir Bocca Vieira de Rezende
Rezende Filho, Flavio Moura
Oliveira, Acary Souza Bulle
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Motor neuron disease is one of the major groups of neurodegenerative diseases, mainly represented by amyotrophic lateral sclerosis. Despite wide genetic and biochemical data regarding its pathophysiological mechanisms, motor neuron disease develops under a complex network of mechanisms not restricted to the unique functions of the alpha motor neurons but which actually involve diverse functions of glial cell interaction. This review aims to expose some of the leading roles of glial cells in the physiological mechanisms of neuron-glial cell interactions and the mechanisms related to motor neuron survival linked to glial cell functions.
Descrição
Citação
Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 74, n. 10, p. 849-854, 2016.