Gene expression alterations related to mania and psychosis in peripheral blood of patients with a first episode of psychosis

Gene expression alterations related to mania and psychosis in peripheral blood of patients with a first episode of psychosis

Author Gouvea, Eduardo Sauerbronn Autor UNIFESP Google Scholar
Ota, Vanessa Kiyomi Autor UNIFESP Google Scholar
Noto, Cristiano Autor UNIFESP Google Scholar
Santoro, Marcos Leite Autor UNIFESP Google Scholar
Spindola, Leticia Maria Autor UNIFESP Google Scholar
Moretti, Patricia Natalia Autor UNIFESP Google Scholar
Carvalho, Carolina M. Autor UNIFESP Google Scholar
Xavier, Gabriela Autor UNIFESP Google Scholar
Rios, A. C. Autor UNIFESP Google Scholar
Sato, Joao Ricardo Autor UNIFESP Google Scholar
Hayashi, Mirian Akemi Furuie Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Cordeiro, Quirino Autor UNIFESP Google Scholar
Belangero, Sintia Iole Autor UNIFESP Google Scholar
Abstract Psychotic disorders affect similar to 3% of the general population and are among the most severe forms of mental diseases. In early stages of psychosis, clinical aspects may be difficult to distinguish from one another. Undifferentiated psychopathology at the first-episode of psychosis (FEP) highlights the need for biomarkers that can improve and refine differential diagnosis. We investigated gene expression differences between patients with FEP-schizophrenia spectrum (SCZ

N = 53) or FEP-Mania (BD

N = 16) and healthy controls (N = 73). We also verified whether gene expression was correlated to severity of psychotic, manic, depressive symptoms and/or functional impairment. All participants were antipsychotic-naive. After the psychiatric interview, blood samples were collected and the expression of 12 psychotic-disorder-related genes was evaluated by quantitative PCR. AKT1 and DICER1 expression levels were higher in BD patients compared with that in SCZ patients and healthy controls, suggesting that expression of these genes is associated more specifically to manic features. Furthermore, MBP and NDEL1 expression levels were higher in SCZ and BD patients than in healthy controls, indicating that these genes are psychosis related (independent of diagnosis). No correlation was found between gene expression and severity of symptoms or functional impairment. Our findings suggest that genes related to neurodevelopment are altered in psychotic disorders, and some might support the differential diagnosis between schizophrenia and bipolar disorder, with a potential impact on the treatment of these disorders.
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 2010/08968-6
FAPESP: 2011/50740-5
FAPESP: 2014/50830-2
FAPESP: 2014/07280-1
FAPESP: 2013/10498-6
FAPESP: 2012/12686-1
Date 2016
Published in Translational Psychiatry. New York, v. 6, p. -, 2016.
ISSN 2158-3188 (Sherpa/Romeo, impact factor)
Publisher Nature Publishing Group
Extent -
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000392130600003

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