Gene expression alterations related to mania and psychosis in peripheral blood of patients with a first episode of psychosis

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dc.citation.volume6
dc.contributor.authorGouvea, Eduardo Sauerbronn [UNIFESP]
dc.contributor.authorOta, Vanessa Kiyomi [UNIFESP]
dc.contributor.authorNoto, Cristiano [UNIFESP]
dc.contributor.authorSantoro, Marcos Leite [UNIFESP]
dc.contributor.authorSpindola, Leticia Maria [UNIFESP]
dc.contributor.authorMoretti, Patricia Natalia [UNIFESP]
dc.contributor.authorCarvalho, Carolina M. [UNIFESP]
dc.contributor.authorXavier, Gabriela [UNIFESP]
dc.contributor.authorRios, A. C. [UNIFESP]
dc.contributor.authorSato, Joao Ricardo [UNIFESP]
dc.contributor.authorHayashi, Mirian Akemi Furuie [UNIFESP]
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.contributor.authorGadelha, Ary [UNIFESP]
dc.contributor.authorBressan, Rodrigo Affonseca [UNIFESP]
dc.contributor.authorCordeiro, Quirino [UNIFESP]
dc.contributor.authorBelangero, Sintia Iole [UNIFESP]
dc.coverageNew York
dc.date.accessioned2020-07-31T12:47:35Z
dc.date.available2020-07-31T12:47:35Z
dc.date.issued2016
dc.description.abstractPsychotic disorders affect similar to 3% of the general population and are among the most severe forms of mental diseases. In early stages of psychosis, clinical aspects may be difficult to distinguish from one another. Undifferentiated psychopathology at the first-episode of psychosis (FEP) highlights the need for biomarkers that can improve and refine differential diagnosis. We investigated gene expression differences between patients with FEP-schizophrenia spectrum (SCZen
dc.description.abstractN = 53) or FEP-Mania (BDen
dc.description.abstractN = 16) and healthy controls (N = 73). We also verified whether gene expression was correlated to severity of psychotic, manic, depressive symptoms and/or functional impairment. All participants were antipsychotic-naive. After the psychiatric interview, blood samples were collected and the expression of 12 psychotic-disorder-related genes was evaluated by quantitative PCR. AKT1 and DICER1 expression levels were higher in BD patients compared with that in SCZ patients and healthy controls, suggesting that expression of these genes is associated more specifically to manic features. Furthermore, MBP and NDEL1 expression levels were higher in SCZ and BD patients than in healthy controls, indicating that these genes are psychosis related (independent of diagnosis). No correlation was found between gene expression and severity of symptoms or functional impairment. Our findings suggest that genes related to neurodevelopment are altered in psychotic disorders, and some might support the differential diagnosis between schizophrenia and bipolar disorder, with a potential impact on the treatment of these disorders.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationIrmandade Santa Casa Misericordia Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Div Genet, Dept Morphol & Genet, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, LiNC Interdisciplinary Lab Clin Neurosci, Sao Paulo, Brazil
dc.description.affiliationUniv Fed ABC, Ctr Math Computat & Cognit, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Res Grp Behav & Mol Neurosci Bipolar Disorder, Sao Paulo, Brazil
dc.description.affiliationUnifespDepartment of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationUnifespGenetics Division, Department of Morphology and Genetics, UNIFESP, São Paulo, Brazil
dc.description.affiliationUnifespLiNC—Interdisciplinary Laboratory of Clinical Neurosciences, UNIFESP, São Paulo, Brazil
dc.description.affiliationUnifespDepartment of Pharmacology, UNIFESP, São Paulo, Brazil
dc.description.affiliationUnifespResearch Group in Behavioral and Molecular Neuroscience of Bipolar Disorder, UNIFESP, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 2010/08968-6
dc.description.sponsorshipIDFAPESP: 2011/50740-5
dc.description.sponsorshipIDFAPESP: 2014/50830-2
dc.description.sponsorshipIDFAPESP: 2014/07280-1
dc.description.sponsorshipIDFAPESP: 2013/10498-6
dc.description.sponsorshipIDFAPESP: 2012/12686-1
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1038/tp.2016.159
dc.identifier.citationTranslational Psychiatry. New York, v. 6, p. -, 2016.
dc.identifier.doi10.1038/tp.2016.159
dc.identifier.fileWOS000392130600003.pdf
dc.identifier.issn2158-3188
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56912
dc.identifier.wosWOS:000392130600003
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofTranslational Psychiatry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleGene expression alterations related to mania and psychosis in peripheral blood of patients with a first episode of psychosisen
dc.typeinfo:eu-repo/semantics/article
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