The effect of the severity of obstructive sleep apnea syndrome on telomere length

The effect of the severity of obstructive sleep apnea syndrome on telomere length

Author Tempaku, Priscila Farias Autor UNIFESP Google Scholar
Mazzotti, Diego Robles Autor UNIFESP Google Scholar
Hirotsu, Camila Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Xavier, Gabriela Autor UNIFESP Google Scholar
Maurya, Pawan Kumar Autor UNIFESP Google Scholar
Rizzo, Lucas Bortolotto Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Belangero, Sintia Iole Autor UNIFESP Google Scholar
Bittencourt, Lia Rita Azeredo Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Abstract Aging is associated with an increase in the prevalence of obstructive sleep apnea syndrome (OSAS) as well as the shortening of telomeres. It is known that OSAS-related factors are stimuli that can contribute to the acceleration of cellular senescence. Thus, the present study aimed to compare the leukocyte telomere length (LTL) between OSAS patients and controls, as well as to verify the correlation between LTL and sleep parameters. We used DNA extracted of 928 individuals from EPISONO to measure the LTL by the quantitative real-time polymerase chain reaction. All individuals were subjected to one full-night polysomnography. LTL was significantly shorter in OSAS patients compared to controls. The results showed negative correlations between LTL and the following variables: apnea-hypopnea index, respiratory disturbance index, desaturation index and wake after sleep onset. LTL was positively correlated with sleep efficiency, total sleep time, basal, minimum and maximum oxygen saturation. Lastly, it was observed that OSAS severity was associated with shorter LTL even after adjusting for sex, age, years of schooling, body mass index, diabetes, stroke and heart attack. In conclusion, our study indicates the presence of an association between LTL and OSAS and a significant impact of severity of OSAS in telomeres shortening.
Keywords sleep
telomeres
obstructive sleep apnea syndrome
aging
Gerotarget
xmlui.dri2xhtml.METS-1.0.item-coverage Orchard Park
Language English
Sponsor Associação Fundo de Incentivo à Psicofarmacologia (AFIP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2014/15259-2
FAPESP: 2015/17549-0
Date 2016
Published in Oncotarget. Orchard Park, v. 7, n. 43, p. 69216-69224, 2016.
ISSN 1949-2553 (Sherpa/Romeo, impact factor)
Publisher Impact Journals Llc
Extent 69216-69224
Origin http://dx.doi.org/10.18632/oncotarget.12293
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000387448300010
URI https://repositorio.unifesp.br/handle/11600/56884

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