The effect of the severity of obstructive sleep apnea syndrome on telomere length

Página do item simplificado
dc.citation.issue43
dc.citation.volume7
dc.contributor.authorTempaku, Priscila Farias [UNIFESP]
dc.contributor.authorMazzotti, Diego Robles [UNIFESP]
dc.contributor.authorHirotsu, Camila [UNIFESP]
dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorXavier, Gabriela [UNIFESP]
dc.contributor.authorMaurya, Pawan Kumar [UNIFESP]
dc.contributor.authorRizzo, Lucas Bortolotto [UNIFESP]
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.contributor.authorBelangero, Sintia Iole [UNIFESP]
dc.contributor.authorBittencourt, Lia Rita Azeredo [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.coverageOrchard Park
dc.date.accessioned2020-07-31T12:47:32Z
dc.date.available2020-07-31T12:47:32Z
dc.date.issued2016
dc.description.abstractAging is associated with an increase in the prevalence of obstructive sleep apnea syndrome (OSAS) as well as the shortening of telomeres. It is known that OSAS-related factors are stimuli that can contribute to the acceleration of cellular senescence. Thus, the present study aimed to compare the leukocyte telomere length (LTL) between OSAS patients and controls, as well as to verify the correlation between LTL and sleep parameters. We used DNA extracted of 928 individuals from EPISONO to measure the LTL by the quantitative real-time polymerase chain reaction. All individuals were subjected to one full-night polysomnography. LTL was significantly shorter in OSAS patients compared to controls. The results showed negative correlations between LTL and the following variables: apnea-hypopnea index, respiratory disturbance index, desaturation index and wake after sleep onset. LTL was positively correlated with sleep efficiency, total sleep time, basal, minimum and maximum oxygen saturation. Lastly, it was observed that OSAS severity was associated with shorter LTL even after adjusting for sex, age, years of schooling, body mass index, diabetes, stroke and heart attack. In conclusion, our study indicates the presence of an association between LTL and OSAS and a significant impact of severity of OSAS in telomeres shortening.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psicobiol, UNIFESP, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, LINC, UNIFESP, Sao Paulo, Brazil
dc.description.affiliationUniv Tubingen, Dept Psychiat, Tubingen, Germany
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Grp Pesquisa Neurociencia Comportamental & Mol Tr, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Dept Morfol & Genet, Sao Paulo, Brazil
dc.description.affiliationAmity Univ Uttar Pradesh, Amity Inst Biotechnol, Noida, India
dc.description.affiliationUnifespDepartamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil
dc.description.affiliationUnifespLaboratório Interdisciplinar de Neurociências Clínicas (LINC), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil
dc.description.affiliationUnifespGrupo de Pesquisa em Neurociência Comportamental e Molecular do Transtorno Bipolar, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil
dc.description.affiliationUnifespDepartamento de Morfologia e Genética, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociação Fundo de Incentivo à Psicofarmacologia (AFIP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2014/15259-2
dc.description.sponsorshipIDFAPESP: 2015/17549-0
dc.format.extent69216-69224
dc.identifierhttp://dx.doi.org/10.18632/oncotarget.12293
dc.identifier.citationOncotarget. Orchard Park, v. 7, n. 43, p. 69216-69224, 2016.
dc.identifier.doi10.18632/oncotarget.12293
dc.identifier.fileWOS000387448300010.pdf
dc.identifier.issn1949-2553
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56884
dc.identifier.wosWOS:000387448300010
dc.language.isoeng
dc.publisherImpact Journals Llc
dc.relation.ispartofOncotarget
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectsleepen
dc.subjecttelomeresen
dc.subjectobstructive sleep apnea syndromeen
dc.subjectagingen
dc.subjectGerotargeten
dc.titleThe effect of the severity of obstructive sleep apnea syndrome on telomere lengthen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000387448300010.pdf
Tamanho:
751.23 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos