Performance of adjuvant treatment correlates with survival in reoperated glioblastomas
Data
2016
Autores
Zanovello, Willey Goncalves 
Malheiros, Suzana Maria Fleury
Stávale, João Norberto
Lanzoni, Oreste Paulo
Canteras, Miguel Montes
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Artigo
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Objective: To analyze cases of recurrent glioblastoma subjected to reoperation at a Brazilian public healthcare service. Methods: A total of 39 patients subjected to reoperation for recurrent glioblastoma at the Department of Neurosurgery, Sao Paulo Hospital, Federal University of Sao Paulo, from January 2000 to December 2013 were retrospectively analyzed. Results: The median overall survival was 20 months (95% confidence interval -CI = 14.9-25.2), and the median survival after reoperation was 9.1 months (95% CI: 2.8-15.4). The performance of adjuvant treatment after the first operation was the single factor associated with overall survival on multivariate analysis (relative risk - RR = 0.3
95% CI = 0.2-0.7)
p = 0.005). Conclusion: The length of survival of patients subjected to reoperation for glioblastoma at a Brazilian public healthcare service was similar to the length reported in the literature. Reoperation should be considered as a therapeutic option for selected patients.
95% CI = 0.2-0.7)
p = 0.005). Conclusion: The length of survival of patients subjected to reoperation for glioblastoma at a Brazilian public healthcare service was similar to the length reported in the literature. Reoperation should be considered as a therapeutic option for selected patients.
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Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 74, n. 11, p. 887-894, 2016.