Cardiac Magnetic Resonance-Verified Myocardial Fibrosis in Chagas Disease: Clinical Correlates and Risk Stratification

Date
2016Author
Uellendahl, Marly [UNIFESP]
Siqueira, Maria Eduarda Menezes de [UNIFESP]
Calado, Eveline Barros [UNIFESP]
Kalil-Filho, Roberto
Sobral, Dario
Ribeiro, Clebia
Oliveira, Wilson
Martins, Silvia
Narula, Jagat
Rochitte, Carlos Eduardo
Type
ArtigoISSN
0066-782XIs part of
Arquivos Brasileiros De CardiologiaDOI
10.5935/abc.20160168Metadata
Show full item recordAbstract
Background: Chagas disease (CD) is an important cause of heart failure and mortality, mainly in Latin America. This study evaluated the morphological and functional characteristics of the heart as well the extent of myocardial fibrosis (MF) in patients with CD by cardiac magnetic resonance (CMR). The prognostic value of MF evaluated by myocardialdelayed enhancement (MDE) was compared with that via Rassi score. Methods: This study assessed 39 patients divided into 2 groups: 28 asymptomatic patients as indeterminate form group (IND) and symptomatic patients as Chagas Heart Disease (CHD) group. All patients underwent CMR using the techniques of cine-MRI and MDE, and the amount of MF was compared with the Rassi score. Results: Regarding the morphological and functional analysis, significant differences were observed between both groups (p < 0.001). Furthermore, there was a strong correlation between the extent of MF and the Rassi score (r = 0.76). Conclusions: CMR is an important technique for evaluating patients with CD, stressing morphological and functional differences in all clinical presentations. The strong correlation with the Rassi score and the extent of MF detected by CMR emphasizes its role in the prognostic stratification of patients with CD.
Citation
Arquivos Brasileiros De Cardiologia. Rio De Janeiro, v. 107, n. 5, p. 460-466, 2016.Keywords
Chagas CardiomyopathyChagas Disease
Magnetic Resonance Spectroscopy
Risk factors
Prognosis
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