Cardiac Magnetic Resonance-Verified Myocardial Fibrosis in Chagas Disease: Clinical Correlates and Risk Stratification

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dc.citation.issue5
dc.citation.volume107
dc.contributor.authorUellendahl, Marly [UNIFESP]
dc.contributor.authorSiqueira, Maria Eduarda Menezes de [UNIFESP]
dc.contributor.authorCalado, Eveline Barros [UNIFESP]
dc.contributor.authorKalil-Filho, Roberto
dc.contributor.authorSobral, Dario
dc.contributor.authorRibeiro, Clebia
dc.contributor.authorOliveira, Wilson
dc.contributor.authorMartins, Silvia
dc.contributor.authorNarula, Jagat
dc.contributor.authorRochitte, Carlos Eduardo
dc.coverageRio De Janeiro
dc.date.accessioned2020-07-31T12:47:21Z
dc.date.available2020-07-31T12:47:21Z
dc.date.issued2016
dc.description.abstractBackground: Chagas disease (CD) is an important cause of heart failure and mortality, mainly in Latin America. This study evaluated the morphological and functional characteristics of the heart as well the extent of myocardial fibrosis (MF) in patients with CD by cardiac magnetic resonance (CMR). The prognostic value of MF evaluated by myocardialdelayed enhancement (MDE) was compared with that via Rassi score. Methods: This study assessed 39 patients divided into 2 groups: 28 asymptomatic patients as indeterminate form group (IND)en
dc.description.abstractand symptomatic patients as Chagas Heart Disease (CHD) group. All patients underwent CMR using the techniques of cine-MRI and MDE, and the amount of MF was compared with the Rassi score. Results: Regarding the morphological and functional analysis, significant differences were observed between both groups (p < 0.001). Furthermore, there was a strong correlation between the extent of MF and the Rassi score (r = 0.76). Conclusions: CMR is an important technique for evaluating patients with CD, stressing morphological and functional differences in all clinical presentations. The strong correlation with the Rassi score and the extent of MF detected by CMR emphasizes its role in the prognostic stratification of patients with CD.en
dc.description.affiliationUniv Sao Paulo, Fac Med, Inst Coracao InCor, Setor Ressonancia Magnet Cardiovasc, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP EPM, Setor Ressonancia Magnet Cardiaca, Sao Paulo, SP, Brazil
dc.description.affiliationDASA Delboni, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Pernambuco, Hosp Oswaldo Cruz, Dept Cardiol, Recife, PE, Brazil
dc.description.affiliationMt Sinai Hosp, Dept Cardiol, New York, NY 10029 USA
dc.description.affiliationUnifespSetor de Ressonância Magnética Cardíaca - Universidade Federal de São Paulo (UNIFESP/EPM)
dc.description.sourceWeb of Science
dc.format.extent460-466
dc.identifierhttp://dx.doi.org/10.5935/abc.20160168
dc.identifier.citationArquivos Brasileiros De Cardiologia. Rio De Janeiro, v. 107, n. 5, p. 460-466, 2016.
dc.identifier.doi10.5935/abc.20160168
dc.identifier.issn0066-782X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56769
dc.identifier.wosWOS:000391430900009
dc.language.isoeng
dc.publisherArquivos Brasileiros Cardiologia
dc.relation.ispartofArquivos Brasileiros De Cardiologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChagas Cardiomyopathyen
dc.subjectChagas Diseaseen
dc.subjectMagnetic Resonance Spectroscopyen
dc.subjectRisk factorsen
dc.subjectPrognosisen
dc.titleCardiac Magnetic Resonance-Verified Myocardial Fibrosis in Chagas Disease: Clinical Correlates and Risk Stratificationen
dc.typeinfo:eu-repo/semantics/article
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