Juvenile myoclonic epilepsy: Challenges on its 60th anniversary
Data
2017
Autores
Yacubian, Elza Márcia Targas 
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Purpose: Since its initial 1957 description, juvenile myoclonic epilepsy (JME) has been recognized as a common epileptic syndrome worldwide. Methods: We reviewed a series of articles on JME to clarify challenges in clinical and pathophysiological findings, treatment and outcome. Results: Typical JME characteristics include: 1) the age at seizure onset between 10 and 25 years
2) the triad of myoclonia, generalized tonic-clonic seizures, and absences, of which only myoclonia is a mandatory criterion
3) cognitive dysfunction that may have impact on interpersonal relationships and social outcome
4) possibility of seizure control in up to 80% of individuals, in particular with the use of sodium valproate
5) a tendency for lifelong seizures with an early morning preponderance
6) after decades from the clinical onset, a possibility to be off medications for a third of the patients, and 7) several prognostic factors. Conclusion: After 60 years, several challenges remain in this complex epileptic syndrome. (C) 2016 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
2) the triad of myoclonia, generalized tonic-clonic seizures, and absences, of which only myoclonia is a mandatory criterion
3) cognitive dysfunction that may have impact on interpersonal relationships and social outcome
4) possibility of seizure control in up to 80% of individuals, in particular with the use of sodium valproate
5) a tendency for lifelong seizures with an early morning preponderance
6) after decades from the clinical onset, a possibility to be off medications for a third of the patients, and 7) several prognostic factors. Conclusion: After 60 years, several challenges remain in this complex epileptic syndrome. (C) 2016 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
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Citação
Seizure-European Journal Of Epilepsy. London, v. 44, p. 48-52, 2017.