Juvenile myoclonic epilepsy: Challenges on its 60th anniversary
| dc.citation.volume | 44 | |
| dc.contributor.author | Yacubian, Elza Márcia Targas [UNIFESP] | |
| dc.coverage | London | |
| dc.date.accessioned | 2020-07-31T12:46:51Z | |
| dc.date.available | 2020-07-31T12:46:51Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | Purpose: Since its initial 1957 description, juvenile myoclonic epilepsy (JME) has been recognized as a common epileptic syndrome worldwide. Methods: We reviewed a series of articles on JME to clarify challenges in clinical and pathophysiological findings, treatment and outcome. Results: Typical JME characteristics include: 1) the age at seizure onset between 10 and 25 years | en |
| dc.description.abstract | 2) the triad of myoclonia, generalized tonic-clonic seizures, and absences, of which only myoclonia is a mandatory criterion | en |
| dc.description.abstract | 3) cognitive dysfunction that may have impact on interpersonal relationships and social outcome | en |
| dc.description.abstract | 4) possibility of seizure control in up to 80% of individuals, in particular with the use of sodium valproate | en |
| dc.description.abstract | 5) a tendency for lifelong seizures with an early morning preponderance | en |
| dc.description.abstract | 6) after decades from the clinical onset, a possibility to be off medications for a third of the patients, and 7) several prognostic factors. Conclusion: After 60 years, several challenges remain in this complex epileptic syndrome. (C) 2016 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. | en |
| dc.description.affiliation | Univ Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, Brazil | |
| dc.description.affiliationUnifesp | Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil | |
| dc.description.source | Web of Science | |
| dc.format.extent | 48-52 | |
| dc.identifier | http://dx.doi.org/10.1016/j.seizure.2016.09.005 | |
| dc.identifier.citation | Seizure-European Journal Of Epilepsy. London, v. 44, p. 48-52, 2017. | |
| dc.identifier.doi | 10.1016/j.seizure.2016.09.005 | |
| dc.identifier.issn | 1059-1311 | |
| dc.identifier.uri | https://repositorio.unifesp.br/handle/11600/56407 | |
| dc.identifier.wos | WOS:000394472800010 | |
| dc.language.iso | eng | |
| dc.publisher | W B Saunders Co Ltd | |
| dc.relation.ispartof | Seizure-European Journal Of Epilepsy | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Juvenile myoclonic epilepsy | en |
| dc.subject | Clinical expression | en |
| dc.subject | Reflex traits | en |
| dc.subject | Pathophysiology | en |
| dc.subject | Treatment | en |
| dc.subject | Prognosis | en |
| dc.title | Juvenile myoclonic epilepsy: Challenges on its 60th anniversary | en |
| dc.type | info:eu-repo/semantics/article |