Increased Dietary Salt Changes Baroreceptor Sensitivity and Intrarenal Renin-Angiotensin System in Goldblatt Hypertension

Increased Dietary Salt Changes Baroreceptor Sensitivity and Intrarenal Renin-Angiotensin System in Goldblatt Hypertension

Author Shimoura, Caroline Gusson Autor UNIFESP Google Scholar
Lincevicius, Gisele Silvério Autor UNIFESP Google Scholar
Nishi, Erika Emy Autor UNIFESP Google Scholar
Girardi, Adriana C. C. Google Scholar
Simon, Karin Argenti Autor UNIFESP Google Scholar
Bergamaschi, Cassia Toledo Autor UNIFESP Google Scholar
Campos, Ruy Ribeiro Autor UNIFESP Google Scholar
Abstract BACKGROUND Renovascular hypertension (2-kidney 1-clip model (2K1C)) is characterized by renin-angiotensin system (RAS) activation. Increased Angiotensin II (AngII) leads to sympathoexcitation, oxidative stress, and alterations in sodium and water balance. AIM The aim of this study was to evaluate whether a discrete increase in sodium chloride intake in 2K1C rats leads to changes in cardiovascular and autonomic function, oxidative stress, and renin angiotensin aldosterone system. METHODS After 4 weeks of induction of hypertension, rats were fed a normal sodium diet (0.4% NaCl) or a high-sodium diet (2% NaCl) for 2 consecutive weeks. Experiments were carried out for 6 weeks after clipping. Mean arterial pressure (MAP), renal sympathetic nerve activity (rSNA), arterial baroreflex control of rSNA, and heart rate (HR) were assessed. Thiobarbituric acid reactive substances and glutathione were measured as indicators of systemic oxidative stress. Angiostensinconverting enzyme (ACE), ACE2, and angiotensinogen were evaluated in clipped and unclipped kidneys as also urinary angiotensinogen and plasma renin activity. Angiotensinogen, plasma renin activity (PRA) and angiotensin-converting enzyme (ACE) and ACE2 in clipped and unclipped kidneys were evaluated. RESULTS High-sodium diet did not change systemic oxidative stress, and basal values of MAP, HR, or rSNA

however, increased renal (-0.7 +/- 0.2 vs. -1.5 +/- 0.1 spikes/s/mm Hg) and cardiac (-0.9 +/- 0.14 vs. -1.5 +/- 0.14 bpm/mm Hg) baroreceptor reflex sensitivity in 2K1C rats. Although there was no alteration in PRA, a high-salt diet significantly decreased urinary angiotensinogen, ACE, and ACE2 expressions in the clipped and unclipped kidneys. CONCLUSIONS Increased arterial baroreceptor control associated with a suppression of the intrarenal RAS in the 2K1C rats on high-salt diet provide a saltresistant effect on hypertension and sympathoexcitation in renovascular hypertensive rats.
Keywords baroreflex dysfunction
blood pressure
high-sodium intake
hypertension
renal sympathetic nerve activity
renin angiotensin aldosterone system
renovascular hypertension
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 2010/04689-5
FAPESP: 2013/22522-9
CNPq: 472613/2013-8
Date 2017
Published in American Journal Of Hypertension. Oxford, v. 30, n. 1, p. 28-36, 2017.
ISSN 0895-7061 (Sherpa/Romeo, impact factor)
Publisher Oxford Univ Press
Extent 28-36
Origin http://dx.doi.org/10.1093/ajh/hpw107
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000397033200009
URI https://repositorio.unifesp.br/handle/11600/56377

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