Increased Dietary Salt Changes Baroreceptor Sensitivity and Intrarenal Renin-Angiotensin System in Goldblatt Hypertension

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dc.citation.issue1
dc.citation.volume30
dc.contributor.authorShimoura, Caroline Gusson [UNIFESP]
dc.contributor.authorLincevicius, Gisele Silvério [UNIFESP]
dc.contributor.authorNishi, Erika Emy [UNIFESP]
dc.contributor.authorGirardi, Adriana C. C.
dc.contributor.authorSimon, Karin Argenti [UNIFESP]
dc.contributor.authorBergamaschi, Cassia Toledo [UNIFESP]
dc.contributor.authorCampos, Ruy Ribeiro [UNIFESP]
dc.coverageOxford
dc.date.accessioned2020-07-31T12:46:49Z
dc.date.available2020-07-31T12:46:49Z
dc.date.issued2017
dc.description.abstractBACKGROUND Renovascular hypertension (2-kidney 1-clip model (2K1C)) is characterized by renin-angiotensin system (RAS) activation. Increased Angiotensin II (AngII) leads to sympathoexcitation, oxidative stress, and alterations in sodium and water balance. AIM The aim of this study was to evaluate whether a discrete increase in sodium chloride intake in 2K1C rats leads to changes in cardiovascular and autonomic function, oxidative stress, and renin angiotensin aldosterone system. METHODS After 4 weeks of induction of hypertension, rats were fed a normal sodium diet (0.4% NaCl) or a high-sodium diet (2% NaCl) for 2 consecutive weeks. Experiments were carried out for 6 weeks after clipping. Mean arterial pressure (MAP), renal sympathetic nerve activity (rSNA), arterial baroreflex control of rSNA, and heart rate (HR) were assessed. Thiobarbituric acid reactive substances and glutathione were measured as indicators of systemic oxidative stress. Angiostensinconverting enzyme (ACE), ACE2, and angiotensinogen were evaluated in clipped and unclipped kidneys as also urinary angiotensinogen and plasma renin activity. Angiotensinogen, plasma renin activity (PRA) and angiotensin-converting enzyme (ACE) and ACE2 in clipped and unclipped kidneys were evaluated. RESULTS High-sodium diet did not change systemic oxidative stress, and basal values of MAP, HR, or rSNAen
dc.description.abstracthowever, increased renal (-0.7 +/- 0.2 vs. -1.5 +/- 0.1 spikes/s/mm Hg) and cardiac (-0.9 +/- 0.14 vs. -1.5 +/- 0.14 bpm/mm Hg) baroreceptor reflex sensitivity in 2K1C rats. Although there was no alteration in PRA, a high-salt diet significantly decreased urinary angiotensinogen, ACE, and ACE2 expressions in the clipped and unclipped kidneys. CONCLUSIONS Increased arterial baroreceptor control associated with a suppression of the intrarenal RAS in the 2K1C rats on high-salt diet provide a saltresistant effect on hypertension and sympathoexcitation in renovascular hypertensive rats.en
dc.description.affiliationUniv Fed Sao Paulo, Cardiovasc Div, Dept Physiol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Heart Inst InCor, Sch Med, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biol Sci, Diadema, Brazil
dc.description.affiliationUnifespCardiovascular Division—Department of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationUnifespDepartment of Biological Sciences, Universidade Federal de São Paulo, Diadema, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 2010/04689-5
dc.description.sponsorshipIDFAPESP: 2013/22522-9
dc.description.sponsorshipIDCNPq: 472613/2013-8
dc.format.extent28-36
dc.identifierhttp://dx.doi.org/10.1093/ajh/hpw107
dc.identifier.citationAmerican Journal Of Hypertension. Oxford, v. 30, n. 1, p. 28-36, 2017.
dc.identifier.doi10.1093/ajh/hpw107
dc.identifier.issn0895-7061
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56377
dc.identifier.wosWOS:000397033200009
dc.language.isoeng
dc.publisherOxford Univ Press
dc.relation.ispartofAmerican Journal Of Hypertension
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbaroreflex dysfunctionen
dc.subjectblood pressureen
dc.subjecthigh-sodium intakeen
dc.subjecthypertensionen
dc.subjectrenal sympathetic nerve activityen
dc.subjectrenin angiotensin aldosterone systemen
dc.subjectrenovascular hypertensionen
dc.titleIncreased Dietary Salt Changes Baroreceptor Sensitivity and Intrarenal Renin-Angiotensin System in Goldblatt Hypertensionen
dc.typeinfo:eu-repo/semantics/article
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