Immune development in HIV-exposed uninfected children born to HIV-infected women

Immune development in HIV-exposed uninfected children born to HIV-infected women

Author Miyamoto, Maristela Autor UNIFESP Google Scholar
Gouvêa, Aida de Fátima Thomé Barbosa Autor UNIFESP Google Scholar
Ono, Erika Autor UNIFESP Google Scholar
Succi, Regina Célia de Menezes Autor UNIFESP Google Scholar
Pahwa, Savita Google Scholar
Moraes-Pinto, Maria Isabel de Autor UNIFESP Google Scholar
Abstract Immunological and clinical findings suggestive of some immune dysfunction have been reported among HIV-exposed uninfected(HEU) children and adolescents. Whether these defects are persistent or transitory is still unknown. HEU pediatric population at birth, 12 months, 6-12 years were evaluated in comparison to healthy age-matched HIV-unexposed controls. Plasma levels of LPS, sCD14, cytokines, lymphocyte immunophenotyping and T-cell receptor excision circles (TREC) were assessed. HEU and controls had similar LPS levels, which remained low from birth to 6-12 years

for plasma sCD14, IL-2, IL-6, IL-7, IL-10, IL-12p70, IL-13, IL-17, IFN-gamma, TNF-alpha, G-CSF, GM-CSF and MCP-1, which increased from birth to 12 months and then decreased at 6-12 years

and for TREC/10(6) PBMC at birth in HEU and controls. By contrast, plasma MIP-1 beta levels were lower in HEU than in controls (p=0.009) at 12 months, and IL-4 levels were higher in HEU than controls (p=0.04) at 6-12 years. Immune activation was higher in HEU at 12 months and at 6-12 years than controls based on frequencies of CD38+HLA-DR+CD8+T cells (p=0.05) and of CD38+HLA-DR+CD4+T cells (p=0.006). Resting memory and activated mature B cells increased from birth to 6-12 years in both groups. The development of the immune system in vertically HEU individuals is comparable to the general population in most parameters, but subtle or transient differences exist. Their role in influencing clinical incidences in HEU is unknown.
Keywords HIV-exposed uninfected
Lymphocyte activation
Cytokines
Lipopolysaccharide
CD14 antigen
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 10/09701-3
FAPESP: 10/09738-4
Date 2017
Published in Revista Do Instituto De Medicina Tropical De Sao Paulo. Sao Paulo, v. 59, p. -, 2017.
ISSN 0036-4665 (Sherpa/Romeo, impact factor)
Publisher Inst Medicina Tropical Sao Paulo
Extent -
Origin http://dx.doi.org/10.1590/S1678-9946201759030
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000403274300006
SciELO ID S0036-46652017005000217 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/56276

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