Immune development in HIV-exposed uninfected children born to HIV-infected women

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dc.citation.volume59
dc.contributor.authorMiyamoto, Maristela [UNIFESP]
dc.contributor.authorGouvêa, Aida de Fátima Thomé Barbosa [UNIFESP]
dc.contributor.authorOno, Erika [UNIFESP]
dc.contributor.authorSucci, Regina Célia de Menezes [UNIFESP]
dc.contributor.authorPahwa, Savita
dc.contributor.authorMoraes-Pinto, Maria Isabel de [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-07-31T12:46:33Z
dc.date.available2020-07-31T12:46:33Z
dc.date.issued2017
dc.description.abstractImmunological and clinical findings suggestive of some immune dysfunction have been reported among HIV-exposed uninfected(HEU) children and adolescents. Whether these defects are persistent or transitory is still unknown. HEU pediatric population at birth, 12 months, 6-12 years were evaluated in comparison to healthy age-matched HIV-unexposed controls. Plasma levels of LPS, sCD14, cytokines, lymphocyte immunophenotyping and T-cell receptor excision circles (TREC) were assessed. HEU and controls had similar LPS levels, which remained low from birth to 6-12 yearsen
dc.description.abstractfor plasma sCD14, IL-2, IL-6, IL-7, IL-10, IL-12p70, IL-13, IL-17, IFN-gamma, TNF-alpha, G-CSF, GM-CSF and MCP-1, which increased from birth to 12 months and then decreased at 6-12 yearsen
dc.description.abstractand for TREC/10(6) PBMC at birth in HEU and controls. By contrast, plasma MIP-1 beta levels were lower in HEU than in controls (p=0.009) at 12 months, and IL-4 levels were higher in HEU than controls (p=0.04) at 6-12 years. Immune activation was higher in HEU at 12 months and at 6-12 years than controls based on frequencies of CD38+HLA-DR+CD8+T cells (p=0.05) and of CD38+HLA-DR+CD4+T cells (p=0.006). Resting memory and activated mature B cells increased from birth to 6-12 years in both groups. The development of the immune system in vertically HEU individuals is comparable to the general population in most parameters, but subtle or transient differences exist. Their role in influencing clinical incidences in HEU is unknown.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Miami, Dept Med, Miami, FL USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Departamento de Pediatria, Divisão de Infectologia Pediátrica, Rua Pedro de Toledo, 781, 9º andar, CEP 04039-032, Vila Clementino, São Paulo, SP, Brazil.
dc.description.provenanceMade available in DSpace on 2020-07-31T12:46:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2017. Added 1 bitstream(s) on 2020-07-31T13:07:06Z : No. of bitstreams: 1 S0036-46652017005000217.pdf: 380985 bytes, checksum: ce1f2369a4e344e6de788695faa52473 (MD5)en
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 10/09701-3
dc.description.sponsorshipIDFAPESP: 10/09738-4
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1590/S1678-9946201759030
dc.identifier.citationRevista Do Instituto De Medicina Tropical De Sao Paulo. Sao Paulo, v. 59, p. -, 2017.
dc.identifier.doi10.1590/S1678-9946201759030
dc.identifier.fileS0036-46652017005000217.pdf
dc.identifier.issn0036-4665
dc.identifier.scieloS0036-46652017005000217
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56276
dc.identifier.wosWOS:000403274300006
dc.language.isoeng
dc.publisherInst Medicina Tropical Sao Paulo
dc.relation.ispartofRevista Do Instituto De Medicina Tropical De Sao Paulo
dc.rightsAcesso aberto
dc.subjectHIV-exposed uninfecteden
dc.subjectLymphocyte activationen
dc.subjectCytokinesen
dc.subjectLipopolysaccharideen
dc.subjectCD14 antigenen
dc.titleImmune development in HIV-exposed uninfected children born to HIV-infected womenen
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