High-resolution Manometry Findings in Patients After Sclerotherapy for Esophageal Varices
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Data
2016
Autores
Herbella, Fernando Augusto Mardiros [UNIFESP]
Colleoni, Ramiro [UNIFESP]
Bot, Luiz [UNIFESP]
Vicentine, Fernando Pompeu Piza [UNIFESP]
Patti, Marco G.
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Background/Aims Endoscopic therapy for esophageal varices may lead to esophageal dysmotility. High-resolution manometry is probably the more adequate tool to measure esophageal motility in these patients. This study aimed to evaluate esophageal motility using high resolution manometry following eradication of esophageal varices by endoscopic sclerotherapy. Methods We studied 21 patients (11 women, age 52 [45-59] years). All patients underwent eradication of esophageal varices with endoscopic sclerotherapy and subsequent high resolution manometry. Results A significant percentage of defective lower esophageal sphincter (basal pressure 14.3 [8.0-20.0] mmHg
43% hypertonic) and hypocontractility (distal esophageal amplitude 50 [31-64] mmHg
proximal esophageal amplitude 40 [31-61] mmHg
distal contractile integral 617 [403-920] mmHg center dot sec center dot cm
48% ineffective) was noticed. Lower sphincter basal pressure and esophageal amplitude correlated inversely with the number of sessions (P < 0.001). No manometric parameter correlated with symptoms or interval between last endoscopy and manometry. Conclusions Esophageal motility after endoscopic sclerotherapy is characterized by: (1) defective lower sphincter and (2) defective and hypotensive peristalsis. Esophageal dysmotility is associated to an increased number of endoscopic sessions, but manometric parameters do not predict symptoms.
43% hypertonic) and hypocontractility (distal esophageal amplitude 50 [31-64] mmHg
proximal esophageal amplitude 40 [31-61] mmHg
distal contractile integral 617 [403-920] mmHg center dot sec center dot cm
48% ineffective) was noticed. Lower sphincter basal pressure and esophageal amplitude correlated inversely with the number of sessions (P < 0.001). No manometric parameter correlated with symptoms or interval between last endoscopy and manometry. Conclusions Esophageal motility after endoscopic sclerotherapy is characterized by: (1) defective lower sphincter and (2) defective and hypotensive peristalsis. Esophageal dysmotility is associated to an increased number of endoscopic sessions, but manometric parameters do not predict symptoms.
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Journal Of Neurogastroenterology And Motility. Gangnam-Gu, v. 22, n. 2, p. 226-230, 2016.