Cytogenetic Biomonitoring in Buccal Mucosa Cells from Women Submitted to Chemotherapy After Mastectomy for Breast Cancer
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2016
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Souza, Ana Carolina Flygare [UNIFESP]
Silva, Victor Hugo Pereira da [UNIFESP]
Seixas, Camila [UNIFESP]
Scudeller, Tânia Terezinha [UNIFESP]
Amaral, Maria Teresa Pace do [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
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In addition to surgery, one of the most widely applied treatments for breast cancer is chemotherapy. Chemotherapy is currently considered efficient in curing this disease
however, the therapy may induce damage to the patient's genetic material. Thus, the aim of this study was to evaluate putative cytotavic and mutagenic effects induced by chemotherapy in women diagnosed with breast cancer. For this purpose, a cross-sectional study was carried out in 42 women, aged 18 to 70 years, allocated according to the diagnosis and stage of breast cancer treatment: control group (healthy) (n=15), chemotherapy group (n=11) and post -chemotherapy group (n=16). Cytotoxicity and mutagenicity were analyzed by the micronucleus test in buccal mucosa cells. A higher frequency (p<0.05) of micronucleated cells was detected in the chemotherapy and post -chemotherapy groups when compared to the control. A higher frequency (p<0.05) of karyorrhexis and pyknosis in the chemotherapy group was also noted. Taken together, our results indicate that chemotherapy induces mutagenicity and cytotavicity in buccal mucosa cells of women diagnosed with breast cancer, being persistent after finishing their treatment.
however, the therapy may induce damage to the patient's genetic material. Thus, the aim of this study was to evaluate putative cytotavic and mutagenic effects induced by chemotherapy in women diagnosed with breast cancer. For this purpose, a cross-sectional study was carried out in 42 women, aged 18 to 70 years, allocated according to the diagnosis and stage of breast cancer treatment: control group (healthy) (n=15), chemotherapy group (n=11) and post -chemotherapy group (n=16). Cytotoxicity and mutagenicity were analyzed by the micronucleus test in buccal mucosa cells. A higher frequency (p<0.05) of micronucleated cells was detected in the chemotherapy and post -chemotherapy groups when compared to the control. A higher frequency (p<0.05) of karyorrhexis and pyknosis in the chemotherapy group was also noted. Taken together, our results indicate that chemotherapy induces mutagenicity and cytotavicity in buccal mucosa cells of women diagnosed with breast cancer, being persistent after finishing their treatment.
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Anticancer Research. Athens, v. 36, n. 4, p. 1955-1958, 2016.