Cytogenetic Biomonitoring in Buccal Mucosa Cells from Women Submitted to Chemotherapy After Mastectomy for Breast Cancer

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dc.citation.issue4
dc.citation.volume36
dc.contributor.authorSouza, Ana Carolina Flygare [UNIFESP]
dc.contributor.authorSilva, Victor Hugo Pereira da [UNIFESP]
dc.contributor.authorSeixas, Camila [UNIFESP]
dc.contributor.authorScudeller, Tânia Terezinha [UNIFESP]
dc.contributor.authorAmaral, Maria Teresa Pace do [UNIFESP]
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.coverageAthens
dc.date.accessioned2020-07-22T13:23:12Z
dc.date.available2020-07-22T13:23:12Z
dc.date.issued2016
dc.description.abstractIn addition to surgery, one of the most widely applied treatments for breast cancer is chemotherapy. Chemotherapy is currently considered efficient in curing this diseaseen
dc.description.abstracthowever, the therapy may induce damage to the patient's genetic material. Thus, the aim of this study was to evaluate putative cytotavic and mutagenic effects induced by chemotherapy in women diagnosed with breast cancer. For this purpose, a cross-sectional study was carried out in 42 women, aged 18 to 70 years, allocated according to the diagnosis and stage of breast cancer treatment: control group (healthy) (n=15), chemotherapy group (n=11) and post -chemotherapy group (n=16). Cytotoxicity and mutagenicity were analyzed by the micronucleus test in buccal mucosa cells. A higher frequency (p<0.05) of micronucleated cells was detected in the chemotherapy and post -chemotherapy groups when compared to the control. A higher frequency (p<0.05) of karyorrhexis and pyknosis in the chemotherapy group was also noted. Taken together, our results indicate that chemotherapy induces mutagenicity and cytotavicity in buccal mucosa cells of women diagnosed with breast cancer, being persistent after finishing their treatment.en
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Dept Biosci, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Dept Management & Hlth Care, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP, Dept Biosci, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP, Dept Management & Hlth Care, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent1955-1958
dc.identifierhttp://ar.iiarjournals.org/content/36/4/1955.long
dc.identifier.citationAnticancer Research. Athens, v. 36, n. 4, p. 1955-1958, 2016.
dc.identifier.issn0250-7005
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56097
dc.identifier.wosWOS:000375450600067
dc.language.isoeng
dc.publisherInt Inst Anticancer Research
dc.relation.ispartofAnticancer Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOral mucosa cellsen
dc.subjectbreast canceren
dc.subjectchemotherapyen
dc.subjectmicronucleus testen
dc.titleCytogenetic Biomonitoring in Buccal Mucosa Cells from Women Submitted to Chemotherapy After Mastectomy for Breast Canceren
dc.typeinfo:eu-repo/semantics/article
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