Change in FVC and survival in chronic fibrotic hypersensitivity pneumonitis
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Data
2018
Autores
Gimenez, Andrea [UNIFESP]
Storrer, Karin Mueller [UNIFESP]
Kuranishi, Lilian Tiemi [UNIFESP]
Soares, Maria Raquel [UNIFESP]
Ferreira, Rimarcs Gomes [UNIFESP]
Pereira, Carlos Alberto de Castro [UNIFESP]
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Resumo
The predictive value of the decline in FVC by >= 10% on survival in patients with fibrotic hypersensitivity pneumonitis is unknown. Of 112 patients included, 66 (59%) had surgical lung biopsies. Patients with >= 10% decline in predicted FVC after 6-12 months had a significantly increased risk of all-cause mortality (median survival 53 months, 95% CI 37 to 69 vs 139 months, 95% CI 66 to 212 months, p= 0.007). On multivariate analysis remained associated with increasing mortality: decline in FVC by >= 10% (HR 4.13, 95% CI 1.96 to 8.70, p=0.005), lower FVC% (HR 1.03, 95% CI 1.01 to 1.05, p=0.003) and with decreasing mortality improvement with antigen avoidance (HR 0.18, 95% CI 0.04 to 0.77, p=0.021).
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Citação
Thorax. London, v. 73, n. 4, p. 391-392, 2018.