Change in FVC and survival in chronic fibrotic hypersensitivity pneumonitis

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dc.citation.issue4
dc.citation.volumev. 73
dc.contributor.authorGimenez, Andrea [UNIFESP]
dc.contributor.authorStorrer, Karin Mueller [UNIFESP]
dc.contributor.authorKuranishi, Lilian Tiemi [UNIFESP]
dc.contributor.authorSoares, Maria Raquel [UNIFESP]
dc.contributor.authorFerreira, Rimarcs Gomes [UNIFESP]
dc.contributor.authorPereira, Carlos Alberto de Castro [UNIFESP]
dc.coverageLondon
dc.date.accessioned2020-07-20T16:31:09Z
dc.date.available2020-07-20T16:31:09Z
dc.date.issued2018
dc.description.abstractThe predictive value of the decline in FVC by >= 10% on survival in patients with fibrotic hypersensitivity pneumonitis is unknown. Of 112 patients included, 66 (59%) had surgical lung biopsies. Patients with >= 10% decline in predicted FVC after 6-12 months had a significantly increased risk of all-cause mortality (median survival 53 months, 95% CI 37 to 69 vs 139 months, 95% CI 66 to 212 months, p= 0.007). On multivariate analysis remained associated with increasing mortality: decline in FVC by >= 10% (HR 4.13, 95% CI 1.96 to 8.70, p=0.005), lower FVC% (HR 1.03, 95% CI 1.01 to 1.05, p=0.003) and with decreasing mortality improvement with antigen avoidance (HR 0.18, 95% CI 0.04 to 0.77, p=0.021).en
dc.description.affiliationUniv Fed Sao Paulo, Interstitial Lung Dis Program, R Sena Madureira 1500, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Interstitial Lung Dis Program, R Sena Madureira 1500, BR-04023062 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent391-392
dc.identifierhttp://dx.doi.org/10.1136/thoraxjnl-2017-210035
dc.identifier.citationThorax. London, v. 73, n. 4, p. 391-392, 2018.
dc.identifier.doi10.1136/thoraxjnl-2017-210035
dc.identifier.issn0040-6376
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55743
dc.identifier.wosWOS:000428933000019
dc.language.isoeng
dc.publisherBmj Publishing Group
dc.relation.ispartofThorax
dc.rightsAcesso restrito
dc.titleChange in FVC and survival in chronic fibrotic hypersensitivity pneumonitisen
dc.typeArtigo
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