Chemical constituents and antileukemic activity of Eugenia dysenterica

Chemical constituents and antileukemic activity of Eugenia dysenterica

Author Vitek, Renan Google Scholar
de Novais, Leice M. R. Google Scholar
Torquato, Heron F. V. Autor UNIFESP Google Scholar
Paredes-Gamero, Edgar J. Autor UNIFESP Google Scholar
de Carvalho, Mario G. Google Scholar
de Sousa, Paulo T., Jr. Google Scholar
Jacinto, Marcos J. Google Scholar
da Silva, Virginia C. Google Scholar
Abstract The study about Eugenia dysenterica led to the isolation of 3-acetyl-urs-12-en-28-oic (1), 3-acetyl-olean-12-en-28-oic acid (2) and isoquercetin (3) from the stem barks, and of 3-O--glucopyranosyl--sitosterol (4), methyl 3-hydroxy-4-methoxybenzoate (5), methyl 4-hydroxyphenyl propionate (6), E-methyl-4-hydroxycinnamate (7), quercetin-3-O-(6??-O-galloyl)--d-glucopyranoside (8) and quercetin-3-O--d-galactopyranoside (9) from the leaves. The structures 1-9 were set through the analysis of their NMR spectroscopic data. Compounds 2, 3 and 5-8 were reported for the first time in the Eugenia genus. Compound 8 reduced cell viability and presented IC50 values 40.3 and 36.7M, for the CCRF-CEM and the Kasumi-1 cells, respectively. [GRAPHICS] .
Keywords Eugenia dysenterica
galloyl flavonol
cell death
cell cycle arrest
cell differentiation
leukemia
xmlui.dri2xhtml.METS-1.0.item-coverage Abingdon
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado do Mato Grosso (FAPEMAT)
Fundacao de Amparo e Pesquisa do Estado de Sao Paulo (FAPESP)
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
INFAR/UNIFESP Confocal
Flow Cytometry Facility
Grant number FAPESP: 2015/16799-3
Date 2017
Published in Natural Product Research. Abingdon, v. 31, n. 16, p. 1930-1934, 2017.
ISSN 1478-6419 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Ltd
Extent 1930-1934
Origin http://dx.doi.org/10.1080/14786419.2016.1261343
Access rights Closed access
Type Article
Web of Science ID WOS:000405712500014
URI https://repositorio.unifesp.br/handle/11600/55519

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