Chemical constituents and antileukemic activity of Eugenia dysenterica

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dc.citation.issue16
dc.citation.volume31
dc.contributor.authorVitek, Renan
dc.contributor.authorde Novais, Leice M. R.
dc.contributor.authorTorquato, Heron F. V. [UNIFESP]
dc.contributor.authorParedes-Gamero, Edgar J. [UNIFESP]
dc.contributor.authorde Carvalho, Mario G.
dc.contributor.authorde Sousa, Paulo T., Jr.
dc.contributor.authorJacinto, Marcos J.
dc.contributor.authorda Silva, Virginia C.
dc.coverageAbingdon
dc.date.accessioned2020-07-17T14:03:35Z
dc.date.available2020-07-17T14:03:35Z
dc.date.issued2017
dc.description.abstractThe study about Eugenia dysenterica led to the isolation of 3-acetyl-urs-12-en-28-oic (1), 3-acetyl-olean-12-en-28-oic acid (2) and isoquercetin (3) from the stem barks, and of 3-O--glucopyranosyl--sitosterol (4), methyl 3-hydroxy-4-methoxybenzoate (5), methyl 4-hydroxyphenyl propionate (6), E-methyl-4-hydroxycinnamate (7), quercetin-3-O-(6??-O-galloyl)--d-glucopyranoside (8) and quercetin-3-O--d-galactopyranoside (9) from the leaves. The structures 1-9 were set through the analysis of their NMR spectroscopic data. Compounds 2, 3 and 5-8 were reported for the first time in the Eugenia genus. Compound 8 reduced cell viability and presented IC50 values 40.3 and 36.7M, for the CCRF-CEM and the Kasumi-1 cells, respectively. [GRAPHICS] .en
dc.description.affiliationUniv Fed Mato Grosso, Programa Posgrad Quim, Cuiaba, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Bioquim, Sao Paulo, Brazil
dc.description.affiliationUniv Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Mogi Das Cruzes, Brazil
dc.description.affiliationUniv Fed Rural Rio de Janeiro, Dept Quim, Rio De Janeiro, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Bioquim, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado do Mato Grosso (FAPEMAT)
dc.description.sponsorshipFundacao de Amparo e Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipINFAR/UNIFESP Confocal
dc.description.sponsorshipFlow Cytometry Facility
dc.description.sponsorshipIDFAPESP: 2015/16799-3
dc.format.extent1930-1934
dc.identifierhttp://dx.doi.org/10.1080/14786419.2016.1261343
dc.identifier.citationNatural Product Research. Abingdon, v. 31, n. 16, p. 1930-1934, 2017.
dc.identifier.doi10.1080/14786419.2016.1261343
dc.identifier.issn1478-6419
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55519
dc.identifier.wosWOS:000405712500014
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNatural Product Research
dc.rightsAcesso restrito
dc.subjectEugenia dysentericaen
dc.subjectgalloyl flavonolen
dc.subjectcell deathen
dc.subjectcell cycle arresten
dc.subjectcell differentiationen
dc.subjectleukemiaen
dc.titleChemical constituents and antileukemic activity of Eugenia dysentericaen
dc.typeArtigo
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