Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Disease

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Date
2017Author
Mateus Brandao, Luiz Eduardo
Morais Ferreira Noga, Diana Aline
Dierschnabel, Aline Lima
das Chagas Campelo, Clarissa Loureiro
Rodrigues Meurer, Ywlliane da Silva
Lima, Ramon Hypolito
Galvao Januario Engelberth, Rovena Clara
Cavalcante, Jeferson Souza
Lima, Clesio Andrade
Marchioro, Murilo
Estevam, Charles dos Santos
Santos, Jose Ronaldo
Silva, Regina Helena [UNIFESP]
Ribeiro, Alessandra Mussi [UNIFESP]
Type
ArtigoISSN
1741-427XIs part of
Evidence-Based Complementary And Alternative MedicineDOI
10.1155/2017/8429290Metadata
Show full item recordAbstract
Passiflora cincinnata Masters is a Brazilian native species of passionflower. This genus is known in the American continent folk medicine for its diuretic and analgesic properties. Nevertheless, few studies investigated possible biological effects of P. cincinnata extracts. Further, evidence of antioxidant actions encourages the investigation of possible neuroprotective effects in animal models of neurodegenerative diseases. This study investigates the effect of the P. cincinnata ethanolic extract (PAS) on mice submitted to a progressive model of Parkinson's disease (PD) induced by reserpine. Male (6-month-old) mice received reserpine (0.1mg/kg, s.c.), every other day, for 40 days, with or without a concomitant treatment with daily injections of PAS (25mg/kg, i.p.). Catalepsy, open field, oralmovements, and plus-maze discriminative avoidance evaluations were performed across treatment, and immunohistochemistry for tyrosine hydroxylase was conducted at the end. The results showed that PAS treatment delayed the onset of motor impairments and prevented the occurrence of increased catalepsy behavior in the premotor phase. However, PAS administration did not modify reserpine-induced cognitive impairments. Moreover, PAS prevented the decrease in tyrosine hydroxylase immunostaining in the substantia nigra pars compacta (SNpc) induced by reserpine. Taken together, our results suggested that PAS exerted a neuroprotective effect in a progressive model of PD.
Citation
Evidence-Based Complementary And Alternative Medicine. London, v. , p. -, 2017.Sponsorship
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Pro-Reitoria de Pesquisa da Universidade Federal do Rio Grande do Norte (PROPESQ/UFRN)
Fundacao de Apoio a Pesquisa do Estado do Rio Grande do Norte (FAPERN/MCT/CNPq/CT-INFRA Grant)
Fundacao de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP)
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