Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Disease

Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Disease

Author Mateus Brandao, Luiz Eduardo Google Scholar
Morais Ferreira Noga, Diana Aline Google Scholar
Dierschnabel, Aline Lima Google Scholar
das Chagas Campelo, Clarissa Loureiro Google Scholar
Rodrigues Meurer, Ywlliane da Silva Google Scholar
Lima, Ramon Hypolito Google Scholar
Galvao Januario Engelberth, Rovena Clara Google Scholar
Cavalcante, Jeferson Souza Google Scholar
Lima, Clesio Andrade Google Scholar
Marchioro, Murilo Google Scholar
Estevam, Charles dos Santos Google Scholar
Santos, Jose Ronaldo Google Scholar
Silva, Regina Helena Autor UNIFESP Google Scholar
Ribeiro, Alessandra Mussi Autor UNIFESP Google Scholar
Abstract Passiflora cincinnata Masters is a Brazilian native species of passionflower. This genus is known in the American continent folk medicine for its diuretic and analgesic properties. Nevertheless, few studies investigated possible biological effects of P. cincinnata extracts. Further, evidence of antioxidant actions encourages the investigation of possible neuroprotective effects in animal models of neurodegenerative diseases. This study investigates the effect of the P. cincinnata ethanolic extract (PAS) on mice submitted to a progressive model of Parkinson's disease (PD) induced by reserpine. Male (6-month-old) mice received reserpine (0.1mg/kg, s.c.), every other day, for 40 days, with or without a concomitant treatment with daily injections of PAS (25mg/kg, i.p.). Catalepsy, open field, oralmovements, and plus-maze discriminative avoidance evaluations were performed across treatment, and immunohistochemistry for tyrosine hydroxylase was conducted at the end. The results showed that PAS treatment delayed the onset of motor impairments and prevented the occurrence of increased catalepsy behavior in the premotor phase. However, PAS administration did not modify reserpine-induced cognitive impairments. Moreover, PAS prevented the decrease in tyrosine hydroxylase immunostaining in the substantia nigra pars compacta (SNpc) induced by reserpine. Taken together, our results suggested that PAS exerted a neuroprotective effect in a progressive model of PD.
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Sponsor Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Pro-Reitoria de Pesquisa da Universidade Federal do Rio Grande do Norte (PROPESQ/UFRN)
Fundacao de Apoio a Pesquisa do Estado do Rio Grande do Norte (FAPERN/MCT/CNPq/CT-INFRA Grant)
Fundacao de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP)
Grant number CNPq: 480115/2010-9
FAPERN/MCT/CNPq/CT-INFRA Grant: 013/2009
FAPESP: 2015/03354-3
Date 2017
Published in Evidence-Based Complementary And Alternative Medicine. London, v. , p. -, 2017.
ISSN 1741-427X (Sherpa/Romeo, impact factor)
Publisher Hindawi Ltd
Extent -
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000407322700001

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