Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Disease

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dc.contributor.authorMateus Brandao, Luiz Eduardo
dc.contributor.authorMorais Ferreira Noga, Diana Aline
dc.contributor.authorDierschnabel, Aline Lima
dc.contributor.authordas Chagas Campelo, Clarissa Loureiro
dc.contributor.authorRodrigues Meurer, Ywlliane da Silva
dc.contributor.authorLima, Ramon Hypolito
dc.contributor.authorGalvao Januario Engelberth, Rovena Clara
dc.contributor.authorCavalcante, Jeferson Souza
dc.contributor.authorLima, Clesio Andrade
dc.contributor.authorMarchioro, Murilo
dc.contributor.authorEstevam, Charles dos Santos
dc.contributor.authorSantos, Jose Ronaldo
dc.contributor.authorSilva, Regina Helena [UNIFESP]
dc.contributor.authorRibeiro, Alessandra Mussi [UNIFESP]
dc.coverageLondon
dc.date.accessioned2020-07-17T14:03:34Z
dc.date.available2020-07-17T14:03:34Z
dc.date.issued2017
dc.description.abstractPassiflora cincinnata Masters is a Brazilian native species of passionflower. This genus is known in the American continent folk medicine for its diuretic and analgesic properties. Nevertheless, few studies investigated possible biological effects of P. cincinnata extracts. Further, evidence of antioxidant actions encourages the investigation of possible neuroprotective effects in animal models of neurodegenerative diseases. This study investigates the effect of the P. cincinnata ethanolic extract (PAS) on mice submitted to a progressive model of Parkinson's disease (PD) induced by reserpine. Male (6-month-old) mice received reserpine (0.1mg/kg, s.c.), every other day, for 40 days, with or without a concomitant treatment with daily injections of PAS (25mg/kg, i.p.). Catalepsy, open field, oralmovements, and plus-maze discriminative avoidance evaluations were performed across treatment, and immunohistochemistry for tyrosine hydroxylase was conducted at the end. The results showed that PAS treatment delayed the onset of motor impairments and prevented the occurrence of increased catalepsy behavior in the premotor phase. However, PAS administration did not modify reserpine-induced cognitive impairments. Moreover, PAS prevented the decrease in tyrosine hydroxylase immunostaining in the substantia nigra pars compacta (SNpc) induced by reserpine. Taken together, our results suggested that PAS exerted a neuroprotective effect in a progressive model of PD.en
dc.description.affiliationUniv Fed Rio Grande do Norte, Natal, RN, Brazil
dc.description.affiliationUniv Fed Sergipe, Sao Cristovao, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipPro-Reitoria de Pesquisa da Universidade Federal do Rio Grande do Norte (PROPESQ/UFRN)
dc.description.sponsorshipFundacao de Apoio a Pesquisa do Estado do Rio Grande do Norte (FAPERN/MCT/CNPq/CT-INFRA Grant)
dc.description.sponsorshipFundacao de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipIDCNPq: 480115/2010-9
dc.description.sponsorshipIDFAPERN/MCT/CNPq/CT-INFRA Grant: 013/2009
dc.description.sponsorshipIDFAPESP: 2015/03354-3
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1155/2017/8429290
dc.identifier.citationEvidence-Based Complementary And Alternative Medicine. London, v. , p. -, 2017.
dc.identifier.doi10.1155/2017/8429290
dc.identifier.fileWOS000407322700001.pdf
dc.identifier.issn1741-427X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55502
dc.identifier.wosWOS:000407322700001
dc.language.isoeng
dc.publisherHindawi Ltd
dc.relation.ispartofEvidence-Based Complementary And Alternative Medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titlePassiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Diseaseen
dc.typeinfo:eu-repo/semantics/article
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