Collagen concentration on the facial skin of postmenopausal women after topical treatment with estradiol and genistein: a randomized double-blind controlled trial
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2017
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Ferraz Carbonel, Adriana Aparecida 
Barbosa de Moraes, Andrea Regina
da Silva Sasso, Gisela Rodrigues
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Objective: The objective of this study is to compare the effects of topical estrogen and genistein (a soy isoflavone) on the facial skin collagen of postmenopausal women not undergoing systemic hormonal therapy.Methods: This is a prospective, double blind, randomized, controlled clinical trial. Volunteer women (N=30) 45-55year old from the Endocrine Gynecology sector of the Gynecology Department of the Federal University of SAo Paulo (UNIFESP). The Ethical Committee of the Federal University of SAo Paulo approved the study (report no. 386/2004
registration on ClinicalTrials.gov NCT01553773), were assigned to topical treatment with either estrogen or genistein for 24weeks. We quantified and compared facial collagen concentration before and after each treatment by performing pre-auricular skin biopsies.Results: Our data showed an increase in the amount of both type I and type III facial collagen by the end of both treatments. However, the outcomes of the estrogen GI (ER) group were superior to the genistein GII (GEN) group, with statistical significance p<000.1Conclusion: Treatment with topical estrogen is superior to genistein, but both have positive impacts on facial skin collagen. Nevertheless, it is still unclear whether prolonged use of genistein and other topical phytoestrogens could produce systemic effects and further research is needed to clarify this question.
registration on ClinicalTrials.gov NCT01553773), were assigned to topical treatment with either estrogen or genistein for 24weeks. We quantified and compared facial collagen concentration before and after each treatment by performing pre-auricular skin biopsies.Results: Our data showed an increase in the amount of both type I and type III facial collagen by the end of both treatments. However, the outcomes of the estrogen GI (ER) group were superior to the genistein GII (GEN) group, with statistical significance p<000.1Conclusion: Treatment with topical estrogen is superior to genistein, but both have positive impacts on facial skin collagen. Nevertheless, it is still unclear whether prolonged use of genistein and other topical phytoestrogens could produce systemic effects and further research is needed to clarify this question.
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Gynecological Endocrinology. Abingdon, v. 33, n. 11, p. 845-848, 2017.