Collagen concentration on the facial skin of postmenopausal women after topical treatment with estradiol and genistein: a randomized double-blind controlled trial

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dc.citation.issue11
dc.citation.volume33
dc.contributor.authorSilva, Lidia Aragao
dc.contributor.authorFerraz Carbonel, Adriana Aparecida [UNIFESP]
dc.contributor.authorBarbosa de Moraes, Andrea Regina [UNIFESP]
dc.contributor.authorSimoes, Ricardo S.
dc.contributor.authorda Silva Sasso, Gisela Rodrigues [UNIFESP]
dc.contributor.authorGoes, Livia [UNIFESP]
dc.contributor.authorNunes, Winnie [UNIFESP]
dc.contributor.authorSimoes, Manuel Jesus{UNIFESP]
dc.contributor.authorPatriarca, Marisa Teresinha [UNIFESP]
dc.coverageAbingdon
dc.date.accessioned2020-07-17T14:03:29Z
dc.date.available2020-07-17T14:03:29Z
dc.date.issued2017
dc.description.abstractObjective: The objective of this study is to compare the effects of topical estrogen and genistein (a soy isoflavone) on the facial skin collagen of postmenopausal women not undergoing systemic hormonal therapy.Methods: This is a prospective, double blind, randomized, controlled clinical trial. Volunteer women (N=30) 45-55year old from the Endocrine Gynecology sector of the Gynecology Department of the Federal University of SAo Paulo (UNIFESP). The Ethical Committee of the Federal University of SAo Paulo approved the study (report no. 386/2004en
dc.description.abstractregistration on ClinicalTrials.gov NCT01553773), were assigned to topical treatment with either estrogen or genistein for 24weeks. We quantified and compared facial collagen concentration before and after each treatment by performing pre-auricular skin biopsies.Results: Our data showed an increase in the amount of both type I and type III facial collagen by the end of both treatments. However, the outcomes of the estrogen GI (ER) group were superior to the genistein GII (GEN) group, with statistical significance p<000.1Conclusion: Treatment with topical estrogen is superior to genistein, but both have positive impacts on facial skin collagen. Nevertheless, it is still unclear whether prolonged use of genistein and other topical phytoestrogens could produce systemic effects and further research is needed to clarify this question.en
dc.description.affiliationUniv Fed Bahia, Salvador, BA, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Morphol & Genet, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Obstet & Gynecol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Morphol & Genet, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Morphol & Genet, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Morphol & Genet, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent845-848
dc.identifierhttp://dx.doi.org/10.1080/09513590.2017.1320708
dc.identifier.citationGynecological Endocrinology. Abingdon, v. 33, n. 11, p. 845-848, 2017.
dc.identifier.doi10.1080/09513590.2017.1320708
dc.identifier.issn0951-3590
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55432
dc.identifier.wosWOS:000415815100005
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofGynecological Endocrinology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCollagenen
dc.subjectestrogensen
dc.subjectgenisteinen
dc.subjectmenopauseen
dc.subjectfaceen
dc.titleCollagen concentration on the facial skin of postmenopausal women after topical treatment with estradiol and genistein: a randomized double-blind controlled trialen
dc.typeinfo:eu-repo/semantics/article
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