Tacrolimus Ointment for Refractory Posterior Blepharitis

Tacrolimus Ointment for Refractory Posterior Blepharitis

Author Sakassegawa-Naves, Fernando Eiji Google Scholar
Moraes Ricci, Helena Maria Google Scholar
Moscovici, Bernardo Kaplan Autor UNIFESP Google Scholar
Miyamoto, Daniela Akemi Google Scholar
Chiacchio, Brenda Biagio Google Scholar
Holzchuh, Ricardo Google Scholar
Santo, Ruth Muyuki Google Scholar
Hida, Richard Yudi Google Scholar
Abstract Purpose: This prospective, randomized, double-blind interventional case series was designed to evaluate the short-term efficacy of 0.03% tacrolimus ointment as a new therapeutic approach for refractory cases of posterior blepharitis.Methods: Forty eyes (20 patients) with posterior blepharitis refractory to previous treatment were randomized. Eighteen eyes (9 patients) were treated with 0.03% tacrolimus ointment and 20 eyes (10 patients) with placebo ointment twice daily. Patients were evaluated with a questionnaire and slit-lamp examination 14days and 28days after treatment, and symptoms and signs of blepharitis were compared to those observed at baseline.Results: We could observe statistical difference in the outcome measurements of meibomian gland secretion, conjunctival hyperemia, telangiectasia of inferior lid, Rose Bengal, and fluorescein scoring for the study group. As for the symptoms score, we observed statistical difference in the symptoms scoring for pruritus and dry eye sensation in the tacrolimus group.Conclusion: This study suggests that topical administration of 0.03% tacrolimus ointment can improve some symptoms and some ocular surface status in patients with refractory posterior blepharitis.
Keywords Blepharitis
meibomian gland dysfunction
posterior blepharitis
tacrolimus
xmlui.dri2xhtml.METS-1.0.item-coverage Philadelphia
Language English
Date 2017
Published in Current Eye Research. Philadelphia, v. 42, n. 11, p. 1440-1444, 2017.
ISSN 0271-3683 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Inc
Extent 1440-1444
Origin http://dx.doi.org/10.1080/02713683.2017.1339805
Access rights Closed access
Type Article
Web of Science ID WOS:000415906800005
URI https://repositorio.unifesp.br/handle/11600/55431

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