Tacrolimus Ointment for Refractory Posterior Blepharitis

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dc.citation.issue11
dc.citation.volume42
dc.contributor.authorSakassegawa-Naves, Fernando Eiji
dc.contributor.authorMoraes Ricci, Helena Maria
dc.contributor.authorMoscovici, Bernardo Kaplan [UNIFESP]
dc.contributor.authorMiyamoto, Daniela Akemi
dc.contributor.authorChiacchio, Brenda Biagio
dc.contributor.authorHolzchuh, Ricardo
dc.contributor.authorSanto, Ruth Muyuki
dc.contributor.authorHida, Richard Yudi
dc.coveragePhiladelphia
dc.date.accessioned2020-07-17T14:03:29Z
dc.date.available2020-07-17T14:03:29Z
dc.date.issued2017
dc.description.abstractPurpose: This prospective, randomized, double-blind interventional case series was designed to evaluate the short-term efficacy of 0.03% tacrolimus ointment as a new therapeutic approach for refractory cases of posterior blepharitis.Methods: Forty eyes (20 patients) with posterior blepharitis refractory to previous treatment were randomized. Eighteen eyes (9 patients) were treated with 0.03% tacrolimus ointment and 20 eyes (10 patients) with placebo ointment twice daily. Patients were evaluated with a questionnaire and slit-lamp examination 14days and 28days after treatment, and symptoms and signs of blepharitis were compared to those observed at baseline.Results: We could observe statistical difference in the outcome measurements of meibomian gland secretion, conjunctival hyperemia, telangiectasia of inferior lid, Rose Bengal, and fluorescein scoring for the study group. As for the symptoms score, we observed statistical difference in the symptoms scoring for pruritus and dry eye sensation in the tacrolimus group.Conclusion: This study suggests that topical administration of 0.03% tacrolimus ointment can improve some symptoms and some ocular surface status in patients with refractory posterior blepharitis.en
dc.description.affiliationUniv Sao Paulo, Dept Ophthalmol, Hosp Clin HCFMUSP, Fac Med, Sao Paulo, Brazil
dc.description.affiliationSanta Casa Misericordia Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.affiliationSanta Casa Misericordia Sao Paulo, Eye Bank, Sao Paulo, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1440-1444
dc.identifierhttp://dx.doi.org/10.1080/02713683.2017.1339805
dc.identifier.citationCurrent Eye Research. Philadelphia, v. 42, n. 11, p. 1440-1444, 2017.
dc.identifier.doi10.1080/02713683.2017.1339805
dc.identifier.issn0271-3683
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55431
dc.identifier.wosWOS:000415906800005
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofCurrent Eye Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBlepharitisen
dc.subjectmeibomian gland dysfunctionen
dc.subjectposterior blepharitisen
dc.subjecttacrolimusen
dc.titleTacrolimus Ointment for Refractory Posterior Blepharitisen
dc.typeinfo:eu-repo/semantics/article
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