Attenuation of motor deficits by hydroethanolic extract of Poincianella pyramidalis in a Parkinson's disease model

Attenuation of motor deficits by hydroethanolic extract of Poincianella pyramidalis in a Parkinson's disease model

Author Lins, Livia Cristina R. F. Google Scholar
Souza, Marina F. Google Scholar
Cintra, Rachel R. Google Scholar
Medeiros, Katty Anne A. L. Google Scholar
Macedo-Lima, Matheus Google Scholar
Moraes, Sabrina Z. C. Google Scholar
Stevam, Charles S. Google Scholar
Almeida, Grace Kelly M. Google Scholar
Santos, Sandra L. Google Scholar
Ribeiro, Alessandra M. Autor UNIFESP Google Scholar
Silva, Regina H. Autor UNIFESP Google Scholar
dos Santos, Jose Ronaldo Google Scholar
Marchioro, Murilo Google Scholar
Abstract The present study aimed to evaluate the possible neuroprotective effect of the hydroethanolic extract of Poincianella pyramidalis (EFIPp) (Tul.) L. P. Queiroz (Fabaceae), an endemic plant found in Northeastern Brazil, commonly used in folk medicine, on the motor deficits induced by repeated treatment with reserpine (RES) in rats. Adult male Wistar rats received 10 s.c. injections of 0.1 mg/kg RES or vehicle (VR), every 48 h, and daily i.p. injections daily of HEPp (25 mg/kg) or vehicle (VE). Throughout treatment, catalepsy behavior and oral movements were scored. After behavioral tests, superoxide dismutase (SOD) and catalase (CAT) activities were evaluated in the prefrontal cortex, hippocampus and striatum. RES treatment induced a progressive increase of catalepsy time in the treated group compared to control groups starting at day 15. RES also increased the number of vacuous chewing movements, tongue protrusions and duration of facial twitching. Treatment with HEPp attenuated the motor deficit in the catalepsy test and delayed the onset of oral movements induced by RES. No significant changes were observed in the antioxidant assay. Taken together, these results show a beneficial effect of HEPp on motor deficits induced by reserpine, suggesting a neuroprotective effect in a rat model of PD.
Keywords Natural Products
Oxidative stress
Motor symptoms
Parkinson's disease
xmlui.dri2xhtml.METS-1.0.item-coverage Santiago
Language English
Sponsor Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Fundação de Apoio a Pesquisa e a Inovação Tecnologica do Estado de Sergipe (FAPITEC)
Pro-reitoria de Pesquisa da Universidade Federal de Sergipe (POSGRAP/UFS)
Date 2017
Published in Boletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas. Santiago, v. 16, n. 2, p. 150-161, 2017.
ISSN 0717-7917 (Sherpa/Romeo, impact factor)
Publisher Univ Santiago Chile Casa
Extent 150-161
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000392703700007

Show full item record


Name: WOS000392703700007.pdf
Size: 433.9Kb
Format: PDF
Open file

This item appears in the following Collection(s)




My Account