Attenuation of motor deficits by hydroethanolic extract of Poincianella pyramidalis in a Parkinson's disease model

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dc.citation.issue2
dc.citation.volume16
dc.contributor.authorLins, Lívia Cristina Rodrigues Ferreira
dc.contributor.authorSouza, Marina Freire de
dc.contributor.authorCintra, Rachel Rocha
dc.contributor.authorMedeiros, Katty Anne Amador de Lucena
dc.contributor.authorMacedo-Lima, Matheus
dc.contributor.authorMoraes, Sabrina Zelice Cruz de
dc.contributor.authorEstevam, Charles dos Santos
dc.contributor.authorAlmeida, Grace Kelly Melo de
dc.contributor.authorSantos, Sandra Lauton
dc.contributor.authorRibeiro, Alessandra Mussi [UNIFESP]
dc.contributor.authorSilva, Regina Helena [UNIFESP]
dc.contributor.authorSantos, José Ronaldo dos
dc.contributor.authorMarchioro, Murilo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.coverageSantiago
dc.date.accessioned2020-07-17T14:02:55Z
dc.date.available2020-07-17T14:02:55Z
dc.date.issued2017
dc.description.abstractThe present study aimed to evaluate the possible neuroprotective effect of the hydroethanolic extract of Poincianella pyramidalis (EFIPp) (Tul.) L. P. Queiroz (Fabaceae), an endemic plant found in Northeastern Brazil, commonly used in folk medicine, on the motor deficits induced by repeated treatment with reserpine (RES) in rats. Adult male Wistar rats received 10 s.c. injections of 0.1 mg/kg RES or vehicle (VR), every 48 h, and daily i.p. injections daily of HEPp (25 mg/kg) or vehicle (VE). Throughout treatment, catalepsy behavior and oral movements were scored. After behavioral tests, superoxide dismutase (SOD) and catalase (CAT) activities were evaluated in the prefrontal cortex, hippocampus and striatum. RES treatment induced a progressive increase of catalepsy time in the treated group compared to control groups starting at day 15. RES also increased the number of vacuous chewing movements, tongue protrusions and duration of facial twitching. Treatment with HEPp attenuated the motor deficit in the catalepsy test and delayed the onset of oral movements induced by RES. No significant changes were observed in the antioxidant assay. Taken together, these results show a beneficial effect of HEPp on motor deficits induced by reserpine, suggesting a neuroprotective effect in a rat model of PD.en
dc.description.abstractEl presente estudio tuvo como objetivo evaluar el posible efecto neuroprotector del extracto hidroalcohólico de Poincianella pyramidalis (EHPp) (Tul.) L. P. Queiroz (Fabaceae), en los déficits motores inducidos por el tratamiento repetido con reserpina (RES) en ratas. Ratas Wistar machos adultos recibieron 10 inyecciones (s.c.) de 0,1 mg/kg de RES o vehículo (VR) a cada 48 h, y inyecciones (i.p.) diarias de EHPp (25 mg/kg) o vehículo (VE). Durante todo el tratamiento se observó el comportamiento de la catalepsia y movimientos orales. Después de análisis de comportamientos, fueron evaluados el superóxido dismutasa (SOD) y las actividades de catalasa (CAT) en la corteza prefrontal, el hipocampo y el cuerpo estriado. El tratamiento con EHPp atenuó el déficit motor en el ensayo de catalepsia y el retraso en el comienzo de los movimientos orales inducidos por RES. No se observaron cambios significativos en el ensayo antioxidante. Estos resultados muestran un efecto beneficioso de EHPp en déficits motores inducidos por RES, sugiriendo un efecto neuroprotector en un modelo de enfermedad de Parkinson.es
dc.description.affiliationUniv Fed Sergipe, Dept Physiol, Sao Cristovao, SE, Brazil
dc.description.affiliationUniv Massachusetts, Neurosci & Behav Program, Amherst, MA 01003 USA
dc.description.affiliationMinist Educ, CAPES Fdn, BR-70040020 Brasilia, DF, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biosci, Santos, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sergipe, Dept Biosci, Itabaiana, SE, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biosci, Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, SP, Brazil
dc.description.provenanceMade available in DSpace on 2020-07-17T14:02:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2017. Added 1 bitstream(s) on 2020-07-17T14:32:58Z : No. of bitstreams: 1 WOS000392703700007.pdf: 433947 bytes, checksum: c6f2c39a1caaa5f219ba0ec00668bd19 (MD5)en
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt
dc.description.sponsorshipFundação de Apoio à Pesquisa e a Inovação Tecnológica do Estado de Sergipe (FAPITEC)pt
dc.description.sponsorshipPró-reitoria de Pesquisa da Universidade Federal de Sergipe (POSGRAP/UFS)pt
dc.format.extent150-161
dc.identifierhttps://blacpma.ms-editions.cl/index.php/blacpma/article/view/173
dc.identifier.citationBoletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas. Santiago, v. 16, n. 2, p. 150-161, 2017.
dc.identifier.fileWOS000392703700007.pdf
dc.identifier.issn0717-7917
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55089
dc.identifier.wosWOS:000392703700007
dc.language.isoeng
dc.publisherUniv Santiago Chile Casa
dc.relation.ispartofBoletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas
dc.rightsAcesso aberto
dc.subjectNatural Productsen
dc.subjectOxidative stressen
dc.subjectMotor symptomsen
dc.subjectReserpineen
dc.subjectParkinson's diseaseen
dc.subjectProductos Naturaleses
dc.subjectEstrés oxidativoes
dc.subjectSíntomas motoreses
dc.subjectReserpinaes
dc.subjectEnfermedad de Parkinsones
dc.titleAttenuation of motor deficits by hydroethanolic extract of Poincianella pyramidalis in a Parkinson's disease modelen
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