NMR Spectroscopy Metabolomics Applied to Crack Cocaine Users and Patients with Schizophrenia: Similar Behavior but Different Molecular Causes

NMR Spectroscopy Metabolomics Applied to Crack Cocaine Users and Patients with Schizophrenia: Similar Behavior but Different Molecular Causes

Author Tasic, Ljubica Google Scholar
de Moraes Pontes, Joao Guilherme Google Scholar
de Souza, Rafael Nogueira Google Scholar
Marreiro Brasil, Antonio Jadson Google Scholar
de Faria Cruz, Guilherme Crispim Google Scholar
Asevedo, Elson Google Scholar
Dal Mas, Caroline Google Scholar
Poppi, Ronei Jesus Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Furuie Hayashi, Mirian Akemi Autor UNIFESP Google Scholar
Tavares Lacerda, Acioly Luiz Autor UNIFESP Google Scholar
Abstract Crack-cocaine abuse and dependence is a severe public health problem. Sometimes, the crack-cocaine smokers show behavioral changes and symptoms very similar to those observed for severe mental disorders, like schizophrenia. Although crackcocaine use can easily be detected in smokers by urine or blood tests, after some time, cocaine biomarkers become untraceable. In addition, schizophrenia diagnosis is limited to clinical interviews, while precise clinical tests for this mental disorder remain unknown. Employing metabolomics based on NMR spectroscopy, herein, we showed that blood serum metabolites might be used for discrimination between crackcocaine users and schizophrenia patients groups. These two groups showed the greatest differences in around eleven keymetabolites. Moreover, seven possible peripheral metabolites might be enough for differentiation of crack-cocaine users and healthy controls. These results may contribute to a better understanding of crack-cocaine biochemical effects, and enable more precise diagnosis when crack-cocaine biomarkers, methylecgonidine or ecgonidine, are absent from the urine or blood of crack-cocaine users.
Keywords crack-cocaine
drug abuse
metabolomics
NMR-spectroscopy
schizophrenia
xmlui.dri2xhtml.METS-1.0.item-coverage Weinheim
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Grant number FAPESP: 2014/18938-8
CNPq: 454234/2014-7
Date 2017
Published in Chemistryselect. Weinheim, v. 2, n. 10, p. 2927-2930, 2017.
ISSN 2365-6549 (Sherpa/Romeo, impact factor)
Publisher Wiley-V C H Verlag Gmbh
Extent 2927-2930
Origin http://dx.doi.org/10.1002/slct.201700009
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000398582400007
URI https://repositorio.unifesp.br/handle/11600/54727

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