NMR Spectroscopy Metabolomics Applied to Crack Cocaine Users and Patients with Schizophrenia: Similar Behavior but Different Molecular Causes

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dc.citation.issue10
dc.citation.volume2
dc.contributor.authorTasic, Ljubica
dc.contributor.authorde Moraes Pontes, Joao Guilherme
dc.contributor.authorde Souza, Rafael Nogueira
dc.contributor.authorMarreiro Brasil, Antonio Jadson
dc.contributor.authorde Faria Cruz, Guilherme Crispim
dc.contributor.authorAsevedo, Elson
dc.contributor.authorDal Mas, Caroline
dc.contributor.authorPoppi, Ronei Jesus
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.contributor.authorFuruie Hayashi, Mirian Akemi [UNIFESP]
dc.contributor.authorTavares Lacerda, Acioly Luiz [UNIFESP]
dc.coverageWeinheim
dc.date.accessioned2020-07-17T14:02:17Z
dc.date.available2020-07-17T14:02:17Z
dc.date.issued2017
dc.description.abstractCrack-cocaine abuse and dependence is a severe public health problem. Sometimes, the crack-cocaine smokers show behavioral changes and symptoms very similar to those observed for severe mental disorders, like schizophrenia. Although crackcocaine use can easily be detected in smokers by urine or blood tests, after some time, cocaine biomarkers become untraceable. In addition, schizophrenia diagnosis is limited to clinical interviews, while precise clinical tests for this mental disorder remain unknown. Employing metabolomics based on NMR spectroscopy, herein, we showed that blood serum metabolites might be used for discrimination between crackcocaine users and schizophrenia patients groups. These two groups showed the greatest differences in around eleven keymetabolites. Moreover, seven possible peripheral metabolites might be enough for differentiation of crack-cocaine users and healthy controls. These results may contribute to a better understanding of crack-cocaine biochemical effects, and enable more precise diagnosis when crack-cocaine biomarkers, methylecgonidine or ecgonidine, are absent from the urine or blood of crack-cocaine users.en
dc.description.affiliationUniv Estadual Campinas, Chem Inst, Dept Organ Chem, Lab Quim Biol, POB 6154, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychiat, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Chem Inst, Dept Analyt Chem, Lab Quimiometria Quim Analit, Campinas, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipIDFAPESP: 2014/18938-8
dc.description.sponsorshipIDCNPq: 454234/2014-7
dc.format.extent2927-2930
dc.identifierhttp://dx.doi.org/10.1002/slct.201700009
dc.identifier.citationChemistryselect. Weinheim, v. 2, n. 10, p. 2927-2930, 2017.
dc.identifier.doi10.1002/slct.201700009
dc.identifier.issn2365-6549
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54727
dc.identifier.wosWOS:000398582400007
dc.language.isoeng
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistryselect
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcrack-cocaineen
dc.subjectdrug abuseen
dc.subjectmetabolomicsen
dc.subjectNMR-spectroscopyen
dc.subjectschizophreniaen
dc.titleNMR Spectroscopy Metabolomics Applied to Crack Cocaine Users and Patients with Schizophrenia: Similar Behavior but Different Molecular Causesen
dc.typeinfo:eu-repo/semantics/article
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