Antileishmanial Activity and Immunomodulatory Effects of Tricin Isolated from Leaves of Casearia arborea (Salicaceae)

Antileishmanial Activity and Immunomodulatory Effects of Tricin Isolated from Leaves of Casearia arborea (Salicaceae)

Author Santos, Augusto L. Autor UNIFESP Google Scholar
Yamamoto, Eduardo S. Google Scholar
Passero, Luiz Felipe D. Google Scholar
Laurenti, Marcia D. Google Scholar
Martins, Ligia F. Google Scholar
Lima, Marta L. Google Scholar
Uemi, Miriam Autor UNIFESP Google Scholar
Soares, Marisi G. Google Scholar
Lago, Joao Henrique G. Google Scholar
Tempone, Andre G. Google Scholar
Sartorelli, Patricia Autor UNIFESP Google Scholar
Abstract Bioactivity-guided fractionation of antileishmanial active extract from leaves of Casearia arborea led to isolation of three metabolites: tricin (1), 1,6 '-di-O-beta-D-vanilloyl glucopyranoside (2) and vanillic acid (3). Compound 1 demonstrated the highest activity against the intracellular amastigotes of Leishmania infantum, with an IC50 value of 56 mu m. Tricin (1) demonstrated selectivity in mammalian cells (SI > 7) and elicited immunomodulatory effect on host cells. The present work suggests that tricin modulated the respiratory burst of macrophages to a leishmanicidal state, contributing to the parasite elimination. Therefore, the natural compound tricin could be further explored in drug design studies for leishmaniasis treatment.
Keywords Casearia arborea
Salicaceae
Tricin
Divanilloyl glucopyranoside
Vanillic acid
Leishmania
Immunomodulation
xmlui.dri2xhtml.METS-1.0.item-coverage Weinheim
Language English
Sponsor CAPES
CNPq
FAPESP
Grant number FAPESP: 2016/24985-4
Date 2017
Published in Chemistry & Biodiversity. Weinheim, v. 14, n. 5, p. -, 2017.
ISSN 1612-1872 (Sherpa/Romeo, impact factor)
Publisher Wiley-V C H Verlag Gmbh
Extent -
Origin http://dx.doi.org/10.1002/cbdv.201600458
Access rights Closed access
Type Article
Web of Science ID WOS:000401239300015
URI https://repositorio.unifesp.br/handle/11600/54598

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