Antileishmanial Activity and Immunomodulatory Effects of Tricin Isolated from Leaves of Casearia arborea (Salicaceae)

dc.citation.issue5
dc.citation.volume14
dc.contributor.authorSantos, Augusto L. [UNIFESP]
dc.contributor.authorYamamoto, Eduardo S.
dc.contributor.authorPassero, Luiz Felipe D.
dc.contributor.authorLaurenti, Marcia D.
dc.contributor.authorMartins, Ligia F.
dc.contributor.authorLima, Marta L.
dc.contributor.authorUemi, Miriam [UNIFESP]
dc.contributor.authorSoares, Marisi G.
dc.contributor.authorLago, Joao Henrique G.
dc.contributor.authorTempone, Andre G.
dc.contributor.authorSartorelli, Patricia [UNIFESP]
dc.coverageWeinheim
dc.date.accessioned2020-07-13T11:53:24Z
dc.date.available2020-07-13T11:53:24Z
dc.date.issued2017
dc.description.abstractBioactivity-guided fractionation of antileishmanial active extract from leaves of Casearia arborea led to isolation of three metabolites: tricin (1), 1,6 '-di-O-beta-D-vanilloyl glucopyranoside (2) and vanillic acid (3). Compound 1 demonstrated the highest activity against the intracellular amastigotes of Leishmania infantum, with an IC50 value of 56 mu m. Tricin (1) demonstrated selectivity in mammalian cells (SI > 7) and elicited immunomodulatory effect on host cells. The present work suggests that tricin modulated the respiratory burst of macrophages to a leishmanicidal state, contributing to the parasite elimination. Therefore, the natural compound tricin could be further explored in drug design studies for leishmaniasis treatment.en
dc.description.affiliationUniv Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Rua Prof Artur Riedel,N 275 Jd Eldorado, BR-09972270 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Med Sch, Lab Pathol Infect Dis, Av Dr Arnaldo,455 Cerqueira Cesar, BR-01246903 Sao Paulo, SP, Brazil
dc.description.affiliationSao Paulo State Univ UNESP, Inst Biosci, Praca Infante Dom Henr,S-N Parque Bitaru, BR-11330900 Sao Vicente, SP, Brazil
dc.description.affiliationAdolfo Lutz Inst, Ctr Parasitol & Mycol, Av Dr Arnaldo,355 Cerqueira Cesar, BR-01246000 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Sao Paulo Trop Med Inst, Ave Dr Eneas Carvalho Aguiar 470, BR-05403000 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Alfenas, Chem Inst, Rua Gabriel Monteiro Silva,700 Ctr, BR-37130001 Alfenas, MG, Brazil
dc.description.affiliationFed Univ ABC, Ctr Nat Sci & Humanities, Ave Estados 5001,Bairro Santa Terezinha, BR-09210580 Santo Andre, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Rua Prof Artur Riedel,N 275 Jd Eldorado, BR-09972270 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCAPES
dc.description.sponsorshipCNPq
dc.description.sponsorshipFAPESP
dc.description.sponsorshipIDFAPESP: 2016/24985-4
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1002/cbdv.201600458
dc.identifier.citationChemistry & Biodiversity. Weinheim, v. 14, n. 5, p. -, 2017.
dc.identifier.doi10.1002/cbdv.201600458
dc.identifier.issn1612-1872
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54598
dc.identifier.wosWOS:000401239300015
dc.language.isoeng
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistry & Biodiversity
dc.rightsAcesso restrito
dc.subjectCasearia arboreaen
dc.subjectSalicaceaeen
dc.subjectTricinen
dc.subjectDivanilloyl glucopyranosideen
dc.subjectVanillic aciden
dc.subjectLeishmaniaen
dc.subjectImmunomodulationen
dc.titleAntileishmanial Activity and Immunomodulatory Effects of Tricin Isolated from Leaves of Casearia arborea (Salicaceae)en
dc.typeArtigo
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