Venous Shunt Versus Venous Ligation for Vascular Damage Control: The Immunohistochemical Evidence

Date
2017Author
de Oliveira Goes Junior, Adenauer Marinho [UNIFESP]
Vieira Abib, Simone de Campos [UNIFESP]
de Seixas Alves, Maria Teresa [UNIFESP]
Venerando da Silva Ferreira, Paulo Sergio [UNIFESP]
de Andrade, Mariseth Carvalho [UNIFESP]
Type
ArtigoISSN
0890-5096Is part of
Annals Of Vascular Surgery41st Annual Meeting of the Vascular-and-Endovascular-Surgery-Society
DOI
10.1016/j.avsg.2016.10.031Metadata
Show full item recordAbstract
Background: To evaluate the expression of immunohistochemical markers of tissue ischemia (iNOS, eNOS, and HSP70) in a vascular damage control experimental model to determine if a venous temporary vascular shunt insertion leads to a better limb perfusion when compared with the ligature of the injured vein. Methods: Experimental study in male Sus Scrofa weighting 40 Kg. Animals were distributed into 5 groups: group 1 animals were submitted to right external iliac artery (EIA) shunting and right external iliac vein (EIV) ligation group 2 animals were submitted to right EIA shunting and right EIV shunting group 3 animals were submitted to right EIV ligation group 4 animals were submitted to right EIV shunting group 5 animals were not submitted to vascular shunting or venous ligation. Transonic Systems flowmeters were used to measure vascular flow on right and left external iliac vessels, and i-STAT (Abbot) portable blood analyzer was used for EIVs blood biochemical analysis. An initial baseline register of invasive arterial pressure, iliac vessels flow, and venous blood analysis was performed. Arterial pressure and iliac vessels flow were taken immediately after right iliac vessels shunting or ligation. Then, hemorrhagic shock was induced by continuous 20 mL/min blood withdraw from the external right jugular vein whereas arterial blood pressure and iliac vessels flow registers were taken every 10 min, and blood samples from EIVs were obtained every 30 min until the vascular flow through right EIA (or through the shunt inserted into the right EIV for group 4 animals) became inexistent or until the animal's death. After the end of the experiments, bilateral hind limb's biopsies were obtained for immunohistochemical analysis. Using image editing and analysis software, the expression of iNOS, eNOS, and HSP70 (3 well-known ischemic associated immunohistochemical markers) was assessed. The mean expression of each marker in the right hind limb was compared between groups. For statistical analysis, Microsoft Office Excel 2007 and BioEstat 5.0 (2007) were used. Results: Immunohistochemical analysis showed no difference regarding the iNOS expression nevertheless, both eNOS and HSP70 expression were statistically more intense (P < 0.05) on group 1 (eNOS = 1.32 HSP70 = 15.05) than on group 2 (eNOS = 0.018 HSP70 = 8.56). Conclusions: The higher expression of eNOS and HSP70 in the right hind limbs of group 1 animals (arterial shunt and venous ligature) than group 2 animals (arterial shunt and venous shunt) suggests that venous ligation is associated with more intense ischemic histological findings than venous shunting.
Citation
Annals Of Vascular Surgery. New York, v. 41, p. 214-224, 2017.Sponsorship
Sao Paulo Research FoundationCollections
- EPM - Artigos [17701]
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