Leishmania enriettii (Muniz & Medina, 1948): A highly diverse parasite is here to stay

Leishmania enriettii (Muniz & Medina, 1948): A highly diverse parasite is here to stay

Author Paranaiba, Larissa F. Google Scholar
Pinheiro, Lucelia J. Google Scholar
Torrecilhas, Ana C. Autor UNIFESP Google Scholar
Macedo, Diego H. Google Scholar
Menezes-Neto, Armando Google Scholar
Tafuri, Wagner L. Google Scholar
Soares, Rodrigo P. Google Scholar
Abstract Leishmaniases are a spectrum of diseases caused by protozoans from the genus Leishmania (Kinetoplastida: Trypanosomatidae) and are divided into 2 main clinical forms: tegumentary leishmaniasis (TL) and visceral leishmaniasis (VL). Transmission occurs after the bite of sandfly vectors (Diptera: Phlebotominae) when females take a blood meal from the vertebrate host [1]. In the New World, several species of Leishmania (similar to 20) cause disease to man, the symptoms and epidemiology of which vary depending on species. However, there are species that are nonpathogenic to humans, such as L. enriettii. In 1946, Medina observed ear lesions in 2 farm-reared guinea pigs (Cavia porcellus [Rodentia: Cavida]) from the neighboring state of Sao Paulo. After lesion analysis, Leishmania was confirmed as the pathogen. The complete L. enriettii description was published by Muniz and Medina in 1948 at the Federal University of Parana A, Brazil [2]. Although this species has been used as a model for cutaneous leishmaniasis (CL), many aspects of its biology remain unknown. In the past 6 years, an increased interest has emerged after the finding of a similar isolate in the red kangaroo (Macrofus rufus) in Australia [3]. This article aims to summarize some of the most important publications on this unique pathogen. It demonstrates a high phenotypic plasticity, being able to infect different vertebrate hosts and vectors. It also discusses recent human and veterinary infections due to other L. enriettii complex members.
xmlui.dri2xhtml.METS-1.0.item-coverage San Francisco
Language English
Sponsor Fundacao de Amparo do Estado de Minas Gerais Programa Pesquisador Mineiro-X
Conselho Nacional de Pesquisa e Desenvolvimento CNPq
Grant number FAPEMIG: PPM-00102-16
Date 2017
Published in Plos Pathogens. San Francisco, v. 13, n. 5, p. -, 2017.
ISSN 1553-7366 (Sherpa/Romeo, impact factor)
Publisher Public Library Science
Extent -
Origin http://dx.doi.org/10.1371/journal.ppat.1006303
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000402877700008
URI https://repositorio.unifesp.br/handle/11600/54566

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