Leishmania enriettii (Muniz & Medina, 1948): A highly diverse parasite is here to stay

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dc.citation.issue5
dc.citation.volume13
dc.contributor.authorParanaiba, Larissa F.
dc.contributor.authorPinheiro, Lucelia J.
dc.contributor.authorTorrecilhas, Ana C. [UNIFESP]
dc.contributor.authorMacedo, Diego H.
dc.contributor.authorMenezes-Neto, Armando
dc.contributor.authorTafuri, Wagner L.
dc.contributor.authorSoares, Rodrigo P.
dc.coverageSan Francisco
dc.date.accessioned2020-07-13T11:53:21Z
dc.date.available2020-07-13T11:53:21Z
dc.date.issued2017
dc.description.abstractLeishmaniases are a spectrum of diseases caused by protozoans from the genus Leishmania (Kinetoplastida: Trypanosomatidae) and are divided into 2 main clinical forms: tegumentary leishmaniasis (TL) and visceral leishmaniasis (VL). Transmission occurs after the bite of sandfly vectors (Diptera: Phlebotominae) when females take a blood meal from the vertebrate host [1]. In the New World, several species of Leishmania (similar to 20) cause disease to man, the symptoms and epidemiology of which vary depending on species. However, there are species that are nonpathogenic to humans, such as L. enriettii. In 1946, Medina observed ear lesions in 2 farm-reared guinea pigs (Cavia porcellus [Rodentia: Cavida]) from the neighboring state of Sao Paulo. After lesion analysis, Leishmania was confirmed as the pathogen. The complete L. enriettii description was published by Muniz and Medina in 1948 at the Federal University of Parana A, Brazil [2]. Although this species has been used as a model for cutaneous leishmaniasis (CL), many aspects of its biology remain unknown. In the past 6 years, an increased interest has emerged after the finding of a similar isolate in the red kangaroo (Macrofus rufus) in Australia [3]. This article aims to summarize some of the most important publications on this unique pathogen. It demonstrates a high phenotypic plasticity, being able to infect different vertebrate hosts and vectors. It also discusses recent human and veterinary infections due to other L. enriettii complex members.en
dc.description.affiliationUniv Fed Minas Gerais, Dept Parasitol, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Dept Patol, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Diadema, SP, Brazil
dc.description.affiliationFdn Oswaldo Cruz Fiocruz, Ctr Pesquisas Rene Rachou, Belo Horizonte, MG, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo do Estado de Minas Gerais Programa Pesquisador Mineiro-X
dc.description.sponsorshipConselho Nacional de Pesquisa e Desenvolvimento CNPq
dc.description.sponsorshipIDFAPEMIG: PPM-00102-16
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1371/journal.ppat.1006303
dc.identifier.citationPlos Pathogens. San Francisco, v. 13, n. 5, p. -, 2017.
dc.identifier.doi10.1371/journal.ppat.1006303
dc.identifier.fileWOS000402877700008.pdf
dc.identifier.issn1553-7366
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54566
dc.identifier.wosWOS:000402877700008
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos Pathogens
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleLeishmania enriettii (Muniz & Medina, 1948): A highly diverse parasite is here to stayen
dc.typeinfo:eu-repo/semantics/article
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