Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America
Nenhuma Miniatura disponível
Data
2017
Autores
Perez-Padilla, Rogelio
Fernandez-Plata, Rosario
Montes de Oca, Maria
Victorina Lopez-Varela, Maria
Jardim, Jose R. [UNIFESP]
Muino, Adriana
Valdivia, Gonzalo
Menezes, Ana Maria B.
Orientadores
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Background Lung-function decline is one of the possible mechanisms leading to Chronic Obstructive Pulmonary Disease (COPD). Methods We analyzed data obtained from two population-based surveys of adults (n = 2026) conducted in the same individuals 5-9 years (y) after their baseline examination in three Latin-American cities. Post BronchoDilator (postBD) FEV1 decline in mL/y, as % predicted/y (% P/y) and % of baseline/y (% B/y) was calculated and the influence of age, gender, BMI, baseline lung function, BD response, exacerbations rate evaluated using multivariate models. Results Expressed in ml/y, the mean annual postBD FEV1 decline was 27 mL (0.22%P, 1.32%B) in patients with baseline COPD and 36 (0.14%P, 1.36%B) in those without. Faster decline (in mL/y) was associated with higher baseline lung function, with significant response to bron-chodilators, older age and smoking at baseline, also in women with chronic cough and phlegm, or >= 2 respiratory exacerbations in the previous year, and in men with asthma. Conclusions Lung function decline in a population- based cohort did not differ in obstructed and nonobstructed individuals, it was proportional to baseline FEV1, and was higher in smokers, elderly, and women with respiratory symptoms.
Descrição
Citação
Plos One. San Francisco, v. 12, n. 5, p. -, 2017.