Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America

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dc.citation.issue5
dc.citation.volume12
dc.contributor.authorPerez-Padilla, Rogelio
dc.contributor.authorFernandez-Plata, Rosario
dc.contributor.authorMontes de Oca, Maria
dc.contributor.authorVictorina Lopez-Varela, Maria
dc.contributor.authorJardim, Jose R. [UNIFESP]
dc.contributor.authorMuino, Adriana
dc.contributor.authorValdivia, Gonzalo
dc.contributor.authorMenezes, Ana Maria B.
dc.coverageSan Francisco
dc.date.accessioned2020-07-13T11:53:14Z
dc.date.available2020-07-13T11:53:14Z
dc.date.issued2017
dc.description.abstractBackground Lung-function decline is one of the possible mechanisms leading to Chronic Obstructive Pulmonary Disease (COPD). Methods We analyzed data obtained from two population-based surveys of adults (n = 2026) conducted in the same individuals 5-9 years (y) after their baseline examination in three Latin-American cities. Post BronchoDilator (postBD) FEV1 decline in mL/y, as % predicted/y (% P/y) and % of baseline/y (% B/y) was calculated and the influence of age, gender, BMI, baseline lung function, BD response, exacerbations rate evaluated using multivariate models. Results Expressed in ml/y, the mean annual postBD FEV1 decline was 27 mL (0.22%P, 1.32%B) in patients with baseline COPD and 36 (0.14%P, 1.36%B) in those without. Faster decline (in mL/y) was associated with higher baseline lung function, with significant response to bron-chodilators, older age and smoking at baseline, also in women with chronic cough and phlegm, or >= 2 respiratory exacerbations in the previous year, and in men with asthma. Conclusions Lung function decline in a population- based cohort did not differ in obstructed and nonobstructed individuals, it was proportional to baseline FEV1, and was higher in smokers, elderly, and women with respiratory symptoms.en
dc.description.affiliationNatl Inst Resp Dis, Mexico City, DF, Mexico
dc.description.affiliationUniv Cent Venezuela, Hosp Univ Caracas, Pulm Div, Caracas, Venezuela
dc.description.affiliationUniv Republica, Fac Med, Montevideo, Uruguay
dc.description.affiliationUniv Fed Sao Paulo, Sch Med, São Paulo, Brazil
dc.description.affiliationUniv Fed Pelotas, Postgrad Program Epidemiol, Pelotas, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sch Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipALAT
dc.description.sponsorshipBoehringer
dc.description.sponsorshipGSK
dc.description.sponsorshipNovartis
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0177032
dc.identifier.citationPlos One. San Francisco, v. 12, n. 5, p. -, 2017.
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0177032
dc.identifier.fileWOS000401314500003.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54470
dc.identifier.wosWOS:000400648500124
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleLung function decline in subjects with and without COPD in a population-based cohort in Latin-Americaen
dc.typeinfo:eu-repo/semantics/article
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