Putative mechanisms of genotoxicity induced by fluoride: a comprehensive review
Data
2017
Autores
Ribeiro, Daniel Araki 
Yujra, Veronica Quispe
Silva, Victor Hugo Pereira da
Claudio, Samuel Rangel
Estadella, Debora
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Genotoxicity is the ability of an agent to produce damage on the DNA molecule. Considering the strong evidence for a relationship between genetic damage and carcinogenesis, to elucidate the putative mechanisms of genotoxicity induced by fluoride are important to measure the degree of risk involved to human populations. The purpose of this article is to provide a comprehensive review on genotoxicity induced by fluoride on the basis of its mechanisms of action. In the last 10 years, all published data showed some evidence related to genotoxicity, which is due to mitochondrial disruption, oxidative stress, and cell cycle disturbances. However, this is an area that still requires a lot of investigation since the published data are not sufficient for clarifying the genotoxicity induced by fluoride. Certainly, the new information will be added to those already established for regulatory purposes as a safe way to promote oral healthcare and prevent oral carcinogenesis.
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Environmental Science And Pollution Research. Heidelberg, v. 24, n. 18, p. 15254-15259, 2017.