Putative mechanisms of genotoxicity induced by fluoride: a comprehensive review

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dc.citation.issue18
dc.citation.volume24
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.authorYujra, Veronica Quispe [UNIFESP]
dc.contributor.authorSilva, Victor Hugo Pereira da [UNIFESP]
dc.contributor.authorClaudio, Samuel Rangel [UNIFESP]
dc.contributor.authorEstadella, Debora [UNIFESP]
dc.contributor.authorViana, Milena de Barros [UNIFESP]
dc.contributor.authorOshima, Celina Tizuko Fujiyama [UNIFESP]
dc.coverageHeidelberg
dc.date.accessioned2020-07-13T11:52:59Z
dc.date.available2020-07-13T11:52:59Z
dc.date.issued2017
dc.description.abstractGenotoxicity is the ability of an agent to produce damage on the DNA molecule. Considering the strong evidence for a relationship between genetic damage and carcinogenesis, to elucidate the putative mechanisms of genotoxicity induced by fluoride are important to measure the degree of risk involved to human populations. The purpose of this article is to provide a comprehensive review on genotoxicity induced by fluoride on the basis of its mechanisms of action. In the last 10 years, all published data showed some evidence related to genotoxicity, which is due to mitochondrial disruption, oxidative stress, and cell cycle disturbances. However, this is an area that still requires a lot of investigation since the published data are not sufficient for clarifying the genotoxicity induced by fluoride. Certainly, the new information will be added to those already established for regulatory purposes as a safe way to promote oral healthcare and prevent oral carcinogenesis.en
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Dept Pathol, Santos, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Dept Biosci, Santos, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biociencias, UNIFESP, Av Ana Costa 95, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP, Dept Pathol, Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP, Dept Biosci, Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biociencias, UNIFESP, Av Ana Costa 95, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.format.extent15254-15259
dc.identifierhttps://dx.doi.org/10.1007/s11356-017-9105-3
dc.identifier.citationEnvironmental Science And Pollution Research. Heidelberg, v. 24, n. 18, p. 15254-15259, 2017.
dc.identifier.doi10.1007/s11356-017-9105-3
dc.identifier.issn0944-1344
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54338
dc.identifier.wosWOS:000404358200004
dc.language.isoeng
dc.publisherSpringer Heidelberg
dc.relation.ispartofEnvironmental Science And Pollution Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectFluorideen
dc.subjectGenotoxicityen
dc.subjectIn vitro studiesen
dc.subjectIn vivo studiesen
dc.subjectDNA damageen
dc.titlePutative mechanisms of genotoxicity induced by fluoride: a comprehensive reviewen
dc.typeinfo:eu-repo/semantics/article
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