Traumatic spinal cord injury: current concepts and treatment update

Traumatic spinal cord injury: current concepts and treatment update

Author Rouanet, Carolina Autor UNIFESP Google Scholar
Reges, Danyelle Autor UNIFESP Google Scholar
Rocha, Eva Autor UNIFESP Google Scholar
Gagliardi, Vivian Autor UNIFESP Google Scholar
Silva, Gisele Sampaio Autor UNIFESP Google Scholar
Abstract Spinal cord injury (SCI) affects 1.3 million North Americans, with more than half occurring after trauma. In Brazil, few studies have evaluated the epidemiology of SCI with an estimated incidence of 16 to 26 per million per year. The final extent of the spinal cord damage results from primary and secondary mechanisms that start at the moment of the injury and go on for days, and even weeks, after the event. There is convincing evidence that hypotension contributes to secondary injury after acute SCI. Surgical decompression aims at relieving mechanical pressure on the microvascular circulation, therefore reducing hypoxia and ischemia. The role of methylprednisolone as a therapeutic option is still a matter of debate, however most guidelines do not recommend its regular use. Neuroprotective therapies aiming to reduce further injury have been studied and many others are underway. Neuroregenerative therapies are being extensively investigated, with cell based therapy being very promising.
Keywords spinal cord injuries
spinal cord compression
spinal cord regeneration
cell- and tissue-based therapy
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo Sp
Language English
Date 2017
Published in Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 75, n. 6, p. 387-393, 2017.
ISSN 0004-282X (Sherpa/Romeo, impact factor)
Publisher Assoc Arquivos Neuro- Psiquiatria
Extent 387-393
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000404476400011
SciELO ID S0004-282X2017000600387 (statistics in SciELO)

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