Traumatic spinal cord injury: current concepts and treatment update

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dc.citation.issue6
dc.citation.volume75
dc.contributor.authorRouanet, Carolina [UNIFESP]
dc.contributor.authorReges, Danyelle [UNIFESP]
dc.contributor.authorRocha, Eva Carolina Andrade [UNIFESP]
dc.contributor.authorGagliardi, Vivian Dias Baptista [UNIFESP]
dc.contributor.authorSilva, Gisele Sampaio [UNIFESP]
dc.coverageSao Paulo Sp
dc.date.accessioned2020-07-13T11:52:56Z
dc.date.available2020-07-13T11:52:56Z
dc.date.issued2017
dc.description.abstractSpinal cord injury (SCI) affects 1.3 million North Americans, with more than half occurring after trauma. In Brazil, few studies have evaluated the epidemiology of SCI with an estimated incidence of 16 to 26 per million per year. The final extent of the spinal cord damage results from primary and secondary mechanisms that start at the moment of the injury and go on for days, and even weeks, after the event. There is convincing evidence that hypotension contributes to secondary injury after acute SCI. Surgical decompression aims at relieving mechanical pressure on the microvascular circulation, therefore reducing hypoxia and ischemia. The role of methylprednisolone as a therapeutic option is still a matter of debate, however most guidelines do not recommend its regular use. Neuroprotective therapies aiming to reduce further injury have been studied and many others are underway. Neuroregenerative therapies are being extensively investigated, with cell based therapy being very promising.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Neurol & Neurocirurgia, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Neurol & Neurocirurgia, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent387-393
dc.identifierhttps://dx.doi.org/10.1590/0004-282X20170048
dc.identifier.citationArquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 75, n. 6, p. 387-393, 2017.
dc.identifier.doi10.1590/0004-282X20170048
dc.identifier.fileS0004-282X2017000600387.pdf
dc.identifier.issn0004-282X
dc.identifier.scieloS0004-282X2017000600387
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54330
dc.identifier.wosWOS:000404476400011
dc.language.isoeng
dc.publisherAssoc Arquivos Neuro- Psiquiatria
dc.relation.ispartofArquivos De Neuro-Psiquiatria
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSpinal cord injuriesen
dc.subjectSpinal cord compressionen
dc.subjectNeurosurgeryen
dc.subjectSpinal cord regenerationen
dc.subjectCell- and tissue-based therapyen
dc.titleTraumatic spinal cord injury: current concepts and treatment updateen
dc.typeinfo:eu-repo/semantics/article
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