Technical challenges of working with extracellular vesicles

Technical challenges of working with extracellular vesicles

Author Ramirez, Marcel I. Google Scholar
Amorim, Maria G. Google Scholar
Gadelha, Catarina Google Scholar
Milic, Ivana Google Scholar
Welsh, Joshua A. Google Scholar
Freitas, Vanessa M. Google Scholar
Nawaz, Muhammad Google Scholar
Akbar, Naveed Google Scholar
Couch, Yvonne Google Scholar
Makin, Laura Google Scholar
Cooke, Fiona Google Scholar
Vettore, Andre L. Autor UNIFESP Google Scholar
Batista, Patricia X. Autor UNIFESP Google Scholar
Freezor, Roberta Google Scholar
Pezuk, Julia A. Google Scholar
Rosa-Fernandes, Livia Google Scholar
Carreira, Ana Claudia O. Google Scholar
Devitt, Andrew Google Scholar
Jacobs, Laura Google Scholar
Silva, Israel T. Google Scholar
Coakley, Gillian Google Scholar
Nunes, Diana N. Google Scholar
Carter, Dave Google Scholar
Palmisano, Giuseppe Google Scholar
Dias-Neto, Emmanuel Google Scholar
Abstract Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with potential applications in diagnosis, prognosis and therapeutic guidance in most pathological conditions. These nano-sized particles transmit signals determined by their protein, lipid, nucleic acid and sugar content, and the unique molecular pattern of EVs dictates the type of signal to be transmitted to recipient cells. However, their small sizes and the limited quantities that can usually be obtained from patient-derived samples pose a number of challenges to their isolation, study and characterization. These challenges and some possible options to overcome them are discussed in this review.
xmlui.dri2xhtml.METS-1.0.item-coverage Cambridge
Language English
Sponsor British Council/Newton Fund, Brazil [203855854]
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil [2012/24574-3, 2015/50257-3, 2014/26897-0, 2014/06863-3]
Associacao Beneficente Alzira Denise Hertzog Silva (ABADHS), Brazil
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil [441878/2014-8, 202077/2015-2]
Ricerca Finalizzata from the Ministero della Salute, Italy [172/GR-2011-02350301]
Science without Borders/CAPES, Brazil [BEX 7057/15-6]
Grant number British Council/Newton Fund, Brazil:203855854
FAPESP: 2012/24574-3, 2015/50257-3, 2014/26897-0, 2014/06863-3
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil : 441878/2014-8, 202077/2015-2
Ricerca Finalizzata from the Ministero della Salute, Italy: 172/GR-2011-02350301
Science without Borders/CAPES, Brazil: BEX 7057/15-6
Date 2018
Published in Nanoscale. Cambridge, v. 10, n. 3, p. 881-906, 2018.
ISSN 2040-3364 (Sherpa/Romeo, impact factor)
Publisher Royal Soc Chemistry
Extent 881-906
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000423259000001

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